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Persistent Inhibition of Cell Growth on Silver Implanted Glassy Polymeric Carbon

Published online by Cambridge University Press:  01 February 2011

Robert L. Zimmerman ,
Ismet Gürhan ,
F. Ozdal-Kurt ,
B. H. Sen ,
Marcello Rodrigues  and
Daryush Ila
Robert L. Zimmerman
Affiliation:
rlzimm@cim.aamu.edu, Alabama A&M University, Radiation Center, 4900 Meridian Street, Normal, AL, 35762, United States, 256 372 5854, 256 372 5868
Ismet Gürhan
Affiliation:
ismetgurhan@yahoo.com, Ege University, Faculty of Engineering, Izmir, 87985, Turkey
F. Ozdal-Kurt
Affiliation:
fozdal@yahoo.com, CBU Faculty of Science, Manisa, 45673, Turkey
B. H. Sen
Affiliation:
bhsen@yahoo.com, EU Faculty of Dentistry, Izmir, 34679, Turkey
Marcello Rodrigues
Affiliation:
mrodrigues@dfm.ffclrp.usp.br, University of São Paulo, Ribeirão Preto, 49100, Brazil
Daryush Ila
Affiliation:
ila@cim.aamu.edu, Alabama A&M University, 4900 Meridian Street, Normal, AL, 35762, United States
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Abstract

We have shown that silver ion implantation or argon ion assisted surface deposition of silver inhibits cell growth on Glassy Polymeric Carbon (GPC), a desirable improvement of current cardiac implants. In vitro biocompatibility tests have been carried out with model cell lines to demonstrate that near surface implantation of silver in GPC can completely inhibit cell attachment on implanted areas while leaving adjacent areas vulnerable to strong cell adhesion. After cleaning and sterilization and more than one year in physiologic solution, the silver implanted GPC persists in inhibiting cell attachment.

Keywords

Cbiomedicaladhesion
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 950: Symposium D – Biosurfaces and Biointerfaces , 2006 , 0950-D04-19
Copyright
Copyright © Materials Research Society 2007

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References

REFERENCES

1. Braunwald, N.S., Bonchek, L.I., J. Thoracic & Cardiovasc. Surg. 54–5, 127 (1967).Google Scholar
2. Rodrigues, M. G., Ila, D., Resende, M. C., Damião, A. and Zimmerman, R. L., “Surface Treatment of Glassy Polymeric Carbon Artifacts for Medical Applications,” Application of Accelerators in Research and Industry, Jerome L. Duggan and I. L. Morgan, editors, (AIP 1999) 1066–1069.Google Scholar
3. Zimmerman, R., Ila, D., Muntele, C., Rodrigues, M ., Poker, D.B. and Hensley, D., “Enhanced Tissue Adhesion by Increased Porosity and Surface Roughness of Carbon Based Biomaterials”, Nuclear Instruments and Methods in Physics Research B191, 825–829 (2002).Google Scholar
4. Patterning of Cell Attachment to Biocompatible Glassy Polymeric Carbon by Silver Ion Implantation, Zimmerman, R., Gurhan, I., Muntele, C., Ila, D., Ozdal-Kurt, F. and Sen, B. H., Materials Research Society Symposium II, San Francisco, April 2006 Google Scholar
5. Zimmerman, R. L., Gürhan, I., Muntele, C., Ila, D., Rodrigues, M., Özdal-Kurt, F. and Sen, B. H., Surface Modification of Materials by Ion Bombardment, Izmir, Turkey, (2005).Google Scholar
6. Ziegler, J. F., Biersack, J. P., The Stopping and Range of Ions in Solids, U. Littmark (Pergamon 1985).Google Scholar
7. Jenkins, G.M. and Kawamura, K., Polymeric Carbons-Carbons Fiber (Cambridge University Press 1976).Google Scholar
8. Jenkins, G.M., Grigson, C.J., J. Biomedical Materials Research 13, 371 (1979).Google Scholar
9. Maleki, H., Ila, D., Jenkins, G.M., Zimmerman, R.L., Evelyn, A.L., Material Research Society Symposium Proceeding 371, 443 (1995).Google Scholar
10. Maleki, H., Holland, L. R., Jenkins, G. M. and Zimmerman, R. L., Carbon 35:2,, 227–234 (1997).Google Scholar
11. Zimmerman, R.L., Ila, D., Jenkins, G.M., Maleki, H., Poker, D.B., Nuclear Instruments and Methods in Physics Research B 106, 550 (1995).Google Scholar
12. Maleki, H., Holland, L.R., Jenkins, G.M., Zimmerman, R.L., Journal of Material Research 11–9, 2368 (1996).Google Scholar
13. Zimmerman, R.L., Ila, D., Poker, D.B., Withrow, S.P., Application of Accelerators in Research and Industry, Duggan & Morgan (Eds), New York, 957 (1996).Google Scholar