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Selective Biofunctionalization all-(111) Surface Silicon Nanowires

Published online by Cambridge University Press:  31 January 2011

Muhammad Masood ,
Songuye Chen ,
Edwin T Carlen  and
Albert Van den Berg
Muhammad Masood
Affiliation:
m.n.masood@ewi.utwente.nl
Songuye Chen
Affiliation:
s.chen@ewi.utwente.nl, Mesa+ Institute University of Twente, Electrical, Computer and Mathematics, Enschede, Netherlands
Edwin T Carlen
Affiliation:
e.t.carlen@ewi.utwente.nl, Mesa+ Institute University of Twente, Electrical, Computer and Mathematics, Enschede, Netherlands
Albert Van den Berg
Affiliation:
a.vandenberg@utwente.nl, Mesa+ Institute University of Twente, Electrical, Computer and Mathematics, Enschede, Netherlands
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Abstract

Selective biomolecular functionalization of our all-(111) surface silicon nanowire (SiNW) biosensors using covalently linked alkyl- monolayers is demonstrated. Monolayers were made using a commercially available six member carbon precursor N-(5-Hexynyl) phthalimide and UV based hydrosylilation reaction. Contact angle and x-ray photoelectron spectroscopy (XPS) measurements were used to characterize the monolayer at different stages on planar Si (111) samples. Terminal amine groups on the monolayer surface were used for further conjugation with (+)-Biotin N-hydroxysuccinimide ester after deprotection of the phthalimide group with a methylamine solution. Selective biofunctionalization was demonstrated by reacting the SiNW-monolayer-biotin surface with 5 nm gold nanoparticles conjugated with streptavidin and subsequent high resolution scanning electron microscopy imaging.

Keywords

nanoscalex-ray photoelectron spectroscopy (XPS)biological
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1236: Symposium SS – Biosurfaces and Biointerfaces , 2009 , 1236-SS08-22
Copyright
Copyright © Materials Research Society 2010

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