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SiO2 Entrapment of Animal Cells for Hybrid Bioartificial Organs

Published online by Cambridge University Press:  01 February 2011

Giovanni Carturan ,
Renzo Dal Monte  and
Maurizio Muraca
Giovanni Carturan
Affiliation:
Department of Materials Engineering, 38050, TN
Renzo Dal Monte
Affiliation:
I.R.B. 36077 Altavilla V.na VI
Maurizio Muraca
Affiliation:
Department of Medical and Surgical Sciences, 35100 PD, Italy
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Abstract

Si-alkoxides in gas phase are reactive towards the surface of animal cells, depositing a homogeneous layer of porous silica. This encapsulation method preserves cell viability and does not alter the hindrance of the biological load.

In the prospective use for the design of a hybrid bioartificial liver, hepatocytes in a collagen matrix can be entrapped by the siliceous deposit which provides definite mechanical stability to the collagen matrix and molecular cutoff vs. high molecular weight proteins, including immunoglobulins. The functionality of the encapsulated cell load is maintained for the expressions of typical liver and pancreas metabolic activities.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 628: Symposium CC – Hybrid Organic/Inorganic Materials , 2000 , CC10.1
Copyright
Copyright © Materials Research Society 2000

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