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Spontaneous Self-Assembly, Functionalization, and Meso-Scale Host-Guest Science of Organic Nanotubes

Published online by Cambridge University Press:  01 February 2011

Naohiro Kameta ,
Mitsutoshi Masuda  and
Toshimi Shimizu
Naohiro Kameta
Affiliation:
n-kameta@aist.go.jp, Japan Science and Technology Agency, SORST, Tsukuba Central 5, 1-1-1 Higashi, Tsukuba, 305-8565, Japan, +81-29-861-4615, +81-29-861-4545
Mitsutoshi Masuda
Affiliation:
m-masuda@aist.go.jp, Japan Science and Technology Agency, SORST, Tsukuba Central 5, 1-1-1 Higashi, Tsukuba, 305-8565, Japan
Toshimi Shimizu
Affiliation:
tshmz-shimizu@aist.go.jp, Japan Science and Technology Agency, SORST, Tsukuba Central 5, 1-1-1 Higashi, Tsukuba, 305-8565, Japan
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Abstract

Self-assembly in water at pH 6 and 10 of a wedge-shaped bolaamphiphile (1), bearing amino and glucose hydrophilic headgroups, was found to give two types of nanotubes with different inner diameters of 20 and 80 nm, respectively. X-ray diffraction and IR measurement revealed that the nanotubes have distinct inner and outer surfaces covered with amino and glucose headgroups, respectively. The nanotubes were able to effectively encapsulate an anionic spherical protein, ferritin, and DNA into the hollow cylinder under neutral pH conditions. Positively charged amino groups in the nanotube hollow cylinder proved to accelerate the encapsulation of the anionic biomacromolecules via electrostatic interaction. Covalent modification of the amino groups with a fluorescent donor dye on the inner surface of the nanotube allowed us to achieve the construction of an optical recognition system for encapsulation of guest molecules. Fluorescence resonance energy transfer (FRET) from the fluorescent donor located on the inner surface to the ferritin labeled with fluorescent acceptor enabled us to visualize the encapsulation and transportation features of the ferritin in the nanochannel shaped by the hollow cylinder structure.

Keywords

nanostructureself-assemblybiomaterial
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1061: Symposium MM – Biomolecular and Biologically Inspired Interfaces and Assemblies , 2007 , 1061-MM09-01
Copyright
Copyright © Materials Research Society 2008

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References

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