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Studies on Biosensing Property and Functionalization of In2O3 and Carbon Nanotube Field Effect Transistor

Published online by Cambridge University Press:  01 February 2011

Fumiaki Ishikawa ,
Chao Li ,
Marco Curreli ,
Mark E. Thompson  and
Chongwu Zhou
Fumiaki Ishikawa
Affiliation:
fishikaw@usc.edu, University of Southern California, EE, 920 West 37th St. SSC514, Los Angeles, CA, 90089, United States
Chao Li
Affiliation:
chaol@usc.edu, University of Southern California, Los Angeles, CA, 90089, United States
Marco Curreli
Affiliation:
curreli@usc.edu, University of Southern California, Los Angeles, CA, 90089, United States
Mark E. Thompson
Affiliation:
met@usc.edu, University of Southern California, Los Angeles, CA, 90089, United States
Chongwu Zhou
Affiliation:
chongwuz@usc.edu, University of Southern California, Los Angeles, CA, 90089, United States
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Abstract

Biosensing property and functionalization of In2O3 nanowire and carbon nanotube field effect transistor were investigated. Low-density lipoproteins adsorbed on their surface were found to give complementary effects on their electrical property, e.g., enhanced conductance in NW and suppressed conductance in CNT. Prostate specific antigen was selectively detected by functionalizing the sensors with PSA antibody via linker molecules. It was found that the exposure to 0.14 nM (5 ng/ml) PSA increases the conductance of In2O3 nanowire by 1.3 %, while 1.4 nM (50 ng/ml) PSA decreases that of carbon nanotube by 2 %. Additionally, selective functionalization of Indium Tin Oxide thin film and In2O3 NWs with probe DNA single strand was achieved by selectively converting hydroquinone into quinone using electrochemistry, as confirmed by the fluorescence study.

Keywords

sensornanoscalebiomedical
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 915: Symposium R – Nanostructured Materials and Hybrid Composites for Gas Sensors and Biomedical Applications , 2006 , 0915-R02-09
Copyright
Copyright © Materials Research Society 2006

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