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Biodegradable Foams for Cell Transplantation

Published online by Cambridge University Press:  15 February 2011

H. Lo ,
S. Kadiyala ,
S. E. Guggino  and
K. W. Leong
H. Lo
Affiliation:
Departments of Chemical Engineering, The Johns Hopkins University, Baltimore, MD 21218
S. Kadiyala
Affiliation:
Biomedical Engineering, The Johns Hopkins University, Baltimore, MD 21218
S. E. Guggino
Affiliation:
Medicine, The Johns Hopkins University, Baltimore, MD 21218
K. W. Leong
Affiliation:
Biomedical Engineering, The Johns Hopkins University, Baltimore, MD 21218
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Abstract

A processing technique based on the principle of phase separation was developed to fabricate three-dimensional microcellular foams to act as templates for cell transplantation. The polymers used to make the foams were polylactic acid (PLLA) and a polyphosphoester (BPA/PP). The resulting foams had relatively uniform, open cells throughout the matrix. The foams could also be fabricated into complex shapes to meet specific design requirements. The foam morphology and microstructure were characterized by mercury porosimetry and scanning electron microscopy. Osteoblast like cells ROS17/2.8 were successfully cultured in the foams. Cell attachment to the foam interior was verified by confocal microscopy. The fabrication technique allows incorporation of drugs or nutrients into the highly porous structure as demonstrated by the intimate dispersion of fluorescein isothiocyanate (FITC) in the matrix.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 331: Symposium T – Biomaterials for Drug and Cell Delivery , 1993 , 41
Copyright
Copyright © Materials Research Society 1994

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