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Designing Tunable Bio-nanostructured Materials via Self-Assembly of Amphiphilic Lipids and Functionalized Nanotubes

Published online by Cambridge University Press:  03 September 2012

Meenakshi Dutt ,
Olga Kuksenok  and
Anna C. Balazs
Meenakshi Dutt
Affiliation:
Chemical and Biochemical Engineering, Rutgers- The State University of New Jersey, Piscataway, New Jersey 08854, USA
Olga Kuksenok
Affiliation:
Chemical and Petroleum Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
Anna C. Balazs
Affiliation:
Chemical and Petroleum Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
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Abstract

Via the Dissipative Particle Dynamics (DPD) approach, we study the self-assembly of hybrid structures comprising lipids and end-functionalized nanotubes. Individual lipids are composed of a hydrophilic head group and two hydrophobic tails. Each bare nanotube encompasses an ABA architecture, with a hydrophobic shaft (B) and two hydrophilic ends (A). To allow for regulated transport through the nanotube, we also introduce hydrophilic hairs at one end of the tube. The amphiphilic lipids are composed of a hydrophilic head group (A) and two hydrophobic tails (B). We select the dimensions of the nanotube architecture to minimize its hydrophobic mismatch with the lipid bilayer. We find the amphiphilic lipids and functionalized nanotubes to self-assemble into a stable hybrid vesicle or a bicelle in the presence of a hydrophilic solvent. We demonstrate that the morphology of the self-assembled functionalized nanotube-lipid hybrid structures is controlled by the rigidity of the lipid molecules and concentration of the nanotubes.

Keywords

self-assemblybiomaterialnanostructure
Type
Articles
Information
MRS Online Proceedings Library (OPL) , Volume 1464: Symposium RR – Molecules to Materials—Multiscale Interfacial Phenomena in Biological and Bio-Inspired Materials , 2012 , mrss12-1464-rr08-09
Copyright
Copyright © Materials Research Society 2012

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References

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