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Detection Limits of Captured Protein on the BioCD

Published online by Cambridge University Press:  02 September 2019

Chad Barden ,
Ming Zhao ,
Xuefeng Wang  and
David D. Nolte
Chad Barden
Affiliation:
Quadraspec, Inc., West Lafayette, IN 47906
Ming Zhao
Affiliation:
Dept. of Physics, Purdue University, West Lafayette, IN 47907, U.S.A.
Xuefeng Wang
Affiliation:
Dept. of Physics, Purdue University, West Lafayette, IN 47907, U.S.A.
David D. Nolte
Affiliation:
Dept. of Physics, Purdue University, West Lafayette, IN 47907, U.S.A.
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Abstract

The BioCD is a spinning biochip that uses quadrature laser interferometry to detect captured protein on the disc surface. We describe the detection limits of protein binding on this optical biosensor. The fundamental metrology limit is 1 picometer for a single 100-micron diameter spot. Under assay conditions for prostate specific antigen, we can detect 25 pg/ml at 10 assays per disc.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1133: Symposium AA – Materials for Optical Sensors in Biomedical Applications , 2008 , 1133-AA03-04
Copyright
Copyright © Materials Research Society 2009

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