Hostname: page-component-5c6d5d7d68-ckgrl Total loading time: 0 Render date: 2024-08-22T08:12:14.468Z Has data issue: false hasContentIssue false
  • English
  • Français

Role of Interfacial Interactions on Mechanical Properties of Biomimetic Composites for Bone Tissue Engineering

Published online by Cambridge University Press:  26 February 2011

Devendra Verma ,
Rahul Bhowmik ,
Bedabibhas Mohanty ,
Dinesh R Katti  and
Kalpana S Katti
Devendra Verma
Affiliation:
devendra.verma@ndsu.edu, North Dakota State University, Civil Engineering, United States
Rahul Bhowmik
Affiliation:
rahul.bhowmik@ndsu.edu, North Dakota State University, Civil Engineering, United States
Bedabibhas Mohanty
Affiliation:
bedabibhas.mohanty@ndsu.edu, North Dakota State University, Civil Engineering, United States
Dinesh R Katti
Affiliation:
dinesh.katti@ndsu.edu, North Dakota State University, Civil Engineering, United States
Kalpana S Katti
Affiliation:
kalpana.katti@ndsu.edu, North Dakota State University, Civil Engineering, United States
Get access

Abstract

Interfaces play an important role in controlling the mechanical properties of composites. Optimum mechanical strength of scaffolds is of prime importance for bone tissue engineering. In the present work, molecular dynamics simulations and experimental studies have been conducted to study effect of interfacial interactions on mechanical properties of composites for bone replacement. In order to mimic biological processes, hydroxyapatite (HAP) is mineralized in presence of polyacrylic acid (PAAc) (in situ HAP). Further, solid and porous composites of in situ HAP with polycaprolactone (PCL) are made. Mechanical tests of composites of in situ HAP with PAAc have shown improved strain recovery, higher modulus/density ratio and also improved mechanical response in simulated body fluid (SBF). Simulation studies indicate potential for calcium bridging between –COO− of PAAc and surface calcium of HAP. This fact is also supported by infrared spectroscopic studies. PAAc modified surfaces of in situ HAP offer means to control the microstructure and mechanical response of porous composites. Nanoindentation experiments indicate that apatite grown on in situ HAP/PCL composites from SBF has improved elastic modulus and hardness. This work gives insight into the interfacial mechanisms responsible for mechanical response as well as bioactivity in biomaterials.

Keywords

bonebiomedicalcomposite
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 898: Symposium L – Mechanical Behavior of Biological and Biomimetic Materials , 2005 , 0898-L08-03
Copyright
Copyright © Materials Research Society 2006

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1. Dankers, P. Y. W., Harmsen, M. C., Brouwer, L. A., Luyn, M. J. A. V., E. W. Meijer. Nature Materials 4, 568 (2005).Google Scholar
2. Katti, K. S.. Colloids and Interfaces B 39, 133 (2004).Google Scholar
3. Seeman, N. C., A.M. Belcher. Proc. Natl. Acad. Sci USA 99, 6452 (2002).Google Scholar
4. Weiner, S., Traub, W. and Wagner, H. D.. J. Struc. Bio. 126, 241 (1999).Google Scholar
5. Katti, K., and Gujjula, P., (Mat. Res. Soc. Proc. 711, Boston, MA, 2001).Google Scholar
6. Katti, K., Turlapati, P., Bhowmik, R. (16th ASCE Engineering Mechanics Conference, University of Washington, Seattle).Google Scholar
7. Verma, D., Katti, K. S., Katti, D. R.. J. Biom. Mater. Res A, In Press (2005).Google Scholar
8. Bhowmik, R., Katti, K. S., Verma, D., Katti, D.R., Submitted to Mat. Sci. Eng. C (2005).Google Scholar