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Self-assembled Materials Containing Complementary Nucleobase Molecular Recognition

Published online by Cambridge University Press:  01 February 2011

Wirasak Smitthipong ,
Arkadiusz Chworos ,
Brian Lin ,
Thorsten Neumann ,
Surekha Gajria ,
Luc Jaeger  and
Matthew Tirrell
Wirasak Smitthipong
Affiliation:
wirasaks@mrl.ucsb.edu, University of California, Materials Research Laboratory, 5121, Santa Barbara, CA, 93106, United States, 805-893-5060, 805-893-8502
Arkadiusz Chworos
Affiliation:
achworos@physics.ucsb.edu, University of California, Department of Physics, Santa Barbara, CA, 93106, United States
Brian Lin
Affiliation:
blin@chem.ucsb.edu, University of California, Department of Chemistry and Biochemistry, Santa Barbara, CA, 93106, United States
Thorsten Neumann
Affiliation:
neumann@mrl.ucsb.edu, University of California, Materials Research Laboratory, Santa Barbara, CA, 93106, United States
Surekha Gajria
Affiliation:
sgajria@chem.ucsb.edu, University of California, Department of Chemistry and Biochemistry, Santa Barbara, CA, 93106, United States
Luc Jaeger
Affiliation:
jaeger@chem.ucsb.edu, University of California, Materials Research Laboratory, Santa Barbara, CA, 93106, United States
Matthew Tirrell
Affiliation:
tirrell@engineering.ucsb.edu, University of California, Materials Research Laboratory, Santa Barbara, CA, 93106, United States
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Abstract

Here we report the nucleic acid/cationic amphiphile based-materials in which we exchange the counter-ions of the polyanionic backbone of the nucleic acids with the cationic amphiphiles to form self-assembled transparent films with the thickness of several microns. Predominantly, single stranded poly(A), poly(U) and double stranded poly(AU) were employed for these studies. Small-angle X-ray scattering (SAXS) experiments suggested lamellar-like structure for all the film samples. However, the molecule length as well as the molecular structure of nucleic acids can affect the topology and mechanical properties of these films. Complementary base-paring of poly(AU) is reported here with comparison to poly(A) and poly(U) complexes.

Keywords

biomaterialbiomimetic (assembly)polymer
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1094: Symposium DD – From Biological Materials to Biomimetic Material Synthesis , 2008 , 1094-DD06-05
Copyright
Copyright © Materials Research Society 2008

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