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Small-Angle Neutron Scattering of Bilayer Vesicles Made with Synthetic Phospholipids

Published online by Cambridge University Press:  15 February 2011

S. F. Trevino ,
Robert lvkov ,
Gary R. Matyas  and
Frank J. Lebeda
S. F. Trevino
Affiliation:
U. S. Army Research Laboratory, APG Md NIST Center for Neutron Research, Gaithersburg MD
Robert lvkov
Affiliation:
NIST Center for Neutron Research, Gaithersburg MD
Gary R. Matyas
Affiliation:
Walter Reed Army Institute of Research, Washington, D.C
Frank J. Lebeda
Affiliation:
U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD
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Abstract

We have used Small-Angle Neutron Scattering to investigate the structure of bilayer lipid membranes in aqueous solution. The lipids consist of equimolar concentrations of two molecules DMPG and DMPC (see text). The structures consist of solvent filled cores surrounded by shells composed of the lipid bilayers. In particular the radii of the core and shell thickness are measured as a function of lipid concentration and temperature. Other features which reveal themselves are vesicle forming ability of the lipids, additional larger structures and inter-vesicle interactions at large vesicle concentrations. The study is motivated by the possible use of these systems as delivery vehicles for various beneficial therapeutic compounds.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 550: Symposium GG/HH/II – Biomedical Materials-Drug Delivery, Implants and Tissue Engr , 1998 , 83
Copyright
Copyright © Materials Research Society 1999

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