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Trigeminal satellite cells modulate neuronal responses to triptans: relevance for migraine therapy

Published online by Cambridge University Press:  10 February 2012

Alice de Corato ,
Alessandro Capuano ,
Diego Currò ,
Giuseppe Tringali ,
Pierluigi Navarra  and
Cinzia Dello Russo
Alice de Corato
Affiliation:
Institute of Pharmacology, Catholic University of Sacred Heart, Rome, Italy
Alessandro Capuano
Affiliation:
Division of Neurology, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, Italy
Diego Currò
Affiliation:
Institute of Pharmacology, Catholic University of Sacred Heart, Rome, Italy
Giuseppe Tringali
Affiliation:
Institute of Pharmacology, Catholic University of Sacred Heart, Rome, Italy
Pierluigi Navarra
Affiliation:
Institute of Pharmacology, Catholic University of Sacred Heart, Rome, Italy
Cinzia Dello Russo*
Affiliation:
Institute of Pharmacology, Catholic University of Sacred Heart, Rome, Italy
*
Correspondence should be addressed to: Cinzia Dello Russo, Institute of Pharmacology, Catholic University of Sacred Heart, Largo F. Vito 1, 00168, Rome, Italy. phone: +390630154253, fax: +3906233235103 email: cinzia.dellorusso@rm.unicatt.it
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Abstract

In the present paper, we have further developed an in vitro model to study neuronal–glial interaction at trigeminal level by characterizing the effects of conditioned medium (CM) collected from activated primary cultures of satellite glial cells (SGCs) on calcitonin gene-related peptide (CGRP) release from rat trigeminal neurons. Moreover, we investigated whether such release is inhibited by a clinically relevant anti-migraine drug, sumatriptan. CM effects were tested on trigeminal neuronal cultures in different conditions of activation and at different time points. Long-term exposures of trigeminal neurons to CM increased directly neuronal CGRP release, which was further enhanced by the exposure to capsaicin. In this framework, the anti-migraine drug sumatriptan was able to inhibit the evoked CGRP release from naïve trigeminal neuron cultures, as well as from trigeminal cultures pre-exposed for 30 min to CM. On the contrary, sumatriptan failed to inhibit evoked CGRP release from trigeminal neurons after prolonged (4 and 8 h) pre-exposures to CM. These findings were confirmed in co-culture experiments (neurons and SGCs), where activation of SGCs or a bradykinin priming were used. Our data demonstrate that SGCs activation could influence neuronal excitability, and that this event affects the neuronal responses to triptans.

Keywords

sumatriptanneuronal sensitizationCGRPtrigeminal satellite cellsmigraine
Type
Research Article
Information
Neuron Glia Biology , Volume 7 , Issue 2-4 , May 2011 , pp. 109 - 116
Copyright
Copyright © Cambridge University Press 2012

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