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Echinococcus granulosus infection in mice: host responses during primary and secondary infection

Published online by Cambridge University Press:  06 April 2009

E. M. Riley ,
J. B. Dixon ,
P. Jenkins  and
O. Ross
E. M. Riley
Affiliation:
Department of Veterinary Pathology, University of Liverpool, P.O. Box 147, Liverpool L69 3BX
J. B. Dixon
Affiliation:
Department of Veterinary Pathology, University of Liverpool, P.O. Box 147, Liverpool L69 3BX
P. Jenkins
Affiliation:
Department of Veterinary Pathology, University of Liverpool, P.O. Box 147, Liverpool L69 3BX
O. Ross
Affiliation:
Department of Veterinary Pathology, University of Liverpool, P.O. Box 147, Liverpool L69 3BX
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Summary

The reaction of Balb/c mice to primary and secondary subcutaneous infection with chinoeoccu.s granulosus protoscoleces (PSC) is described. From 3 to 14 days following primary exposure to PSC, draining lymph nodes increase in weight and there is expansion of T and B lymphocyte populations, enhancement of in vitro lymphocyte transformational responses and production of PSC-specific 1gM and IgE antibodies. Despite the persistence of viable PSC in host tissues, lymphocyte responses decline to pre-infection values over the period 3–8 weeks post-infection. Secondary exposure to PSC immediately induces lympho proliferation, enhancement of transformational responses, production of IgE antibody and encapsulation of PSC by inflammatory cells. Although specific antibody levels remain high until at least 8 weeks after challenge infection, lymphocyte activity begins to decline after 4 days and is profoundly suppressed by 10 days. Parasite viability appears to be significantly reduced in secondary, as opposed to primary, infection and is associated with the accumulation of large numbers of eosinophils, mast cells and macrophages in infected tissues.

Type
Research Article
Information
Parasitology , Volume 92 , Issue 2 , April 1986 , pp. 391 - 403
Copyright
Copyright © Cambridge University Press 1986

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References

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