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The effect of Trichinella spiralis and Trichinella pseudospiralis on the mechanical properties of mammalian diaphragm muscle

Published online by Cambridge University Press:  06 April 2009

M. D. Winter ,
M. L. Ball ,
J. D. Altringham  and
D. L. Lee
M. D. Winter
Affiliation:
Department of Pure and Applied Biology, University of Leeds, Leeds LS2 9JT
M. L. Ball
Affiliation:
Department of Pure and Applied Biology, University of Leeds, Leeds LS2 9JT
J. D. Altringham
Affiliation:
Department of Pure and Applied Biology, University of Leeds, Leeds LS2 9JT
D. L. Lee
Affiliation:
Department of Pure and Applied Biology, University of Leeds, Leeds LS2 9JT
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Summary

The isometric mechanical properties of diaphragm muscle were studied in mice infected with either Trichinella spiralis or Trichinella pseudospiralis. Measurements of muscle stress were taken at 15, 20, 30 and 40 days post-infection. Infected diaphragm muscle showed a significant (P < 0·001) reduction in muscle stress during both twitch and tetanic contractions when compared with muscle from control animals. T. spiralis caused a significant reduction in resistance to muscle fatigue. The consequences of these changes in muscle function to host pathology are discussed, and related to previous work on the effects of Trichinella on host biochemistry and the immune response.

Keywords

Trichinella spiralisTrichinella pseudospiralisdiaphragmmusclemechanical properties
Type
Research Article
Information
Parasitology , Volume 109 , Issue 1 , July 1994 , pp. 129 - 134
Copyright
Copyright © Cambridge University Press 1994

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References

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