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Evolutionary pressures in the spread and persistence of infectious agents in vertebrate populations

Published online by Cambridge University Press:  06 April 2009

R. M. Anderson
R. M. Anderson
Affiliation:
Centre for the Epidemiology of Infectious Disease, Department of Zoology, University of Oxford, Oxford OX1 3PS
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Summary

Infectious agents have considerable potential to regulate or constrain the population growth of vertebrate hosts in natural habitats. A broad theoretical framework provides many insights into how the biology of the parasite and the demography of the host interact to determine this impact. It may manifest itself as a steady influence over time via stable endemic infection or in a recurrent epidemic fashion, sometimes with unpredictable intervals between epidemics depending on the generation time of the pathogen (time from infection to recovery or host death), its ability to induce lasting immunity and the population growth rate of the host species. Building on these notions, the paper focuses on recent work on the population dynamics of genetically variable pathogen populations and examines the factors that determine the evolution of virulence and the maintenance of genetic diversity in both host and pathogen. Recent research extends conventional theoretical templates to include population genetic elements and the within-host dynamics of the parasite and its interaction with the vertebrate immune system.

Keywords

Population dynamicsmathematical modelswithin-host dynamicsevolutiongenetic diversity
Type
Research Article
Information
Parasitology , Volume 111 , Supplement S1: Ecology of wildlife host-parasite interactions , January 1995 , pp. S15 - S31
Copyright
Copyright © Cambridge University Press 1995

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