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In vivo response of Mesocestoides vogae to human insulin

Published online by Cambridge University Press:  12 December 2008

L. CANCLINI  and
A. ESTEVES
L. CANCLINI
Affiliation:
Biochemistry Section, Department of Cellular and Molecular Biology, Faculty of Sciences, University of the Republic of Uruguay, Iguá 4225, 11400Montevideo, Uruguay
A. ESTEVES*
Affiliation:
Biochemistry Section, Department of Cellular and Molecular Biology, Faculty of Sciences, University of the Republic of Uruguay, Iguá 4225, 11400Montevideo, Uruguay
*
*Corresponding author: Biochemistry Section, Faculty of Sciences, Iguá 4225, 11400Montevideo, Uruguay. Fax: +598 (2) 525 2095. E-mail: aesteves@fcien.edu.uy
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Summary

Successful host invasion by parasitic helminths involves detection and appropriate response to a range of host-derived signals. Insulin signal response pathways are ancient and highly-conserved throughout the metazoans. However, very little is known about helminth insulin signalling and the potential role it may play in host-parasite interactions. The response of Mesocestoides vogae (Cestoda: Cyclophyllidea) larvae to human insulin was investigated, focusing on tyrosine-phosphorylation status, glucose content, survival and asexual reproduction rate. Parasite larvae were challenged with different levels of insulin for variable periods. The parameters tested were influenced by human insulin, and suggested a host-parasite molecular dialogue.†

Keywords

Mesocestoides vogaeinsulinprotein tyrosine kinasehost-parasite interactions
Type
Research Article
Information
Parasitology , Volume 136 , Issue 2 , February 2009 , pp. 203 - 209
Copyright
Copyright © 2008 Cambridge University Press

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