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The inactivation of plant viruses by radiations

II. The relation between inactivation dose and size of virus

Published online by Cambridge University Press:  06 April 2009

D. E. Lea  and
Kenneth M. Smith
D. E. Lea
Affiliation:
Strangeways Research Laboratory, and Plant Virus Research Station, Cambridge
Kenneth M. Smith
Affiliation:
Strangeways Research Laboratory, and Plant Virus Research Station, Cambridge
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Extract

Experiments are described on the inactivation by gamma-rays, X-rays, and alpha-rays of the viruses of tomato bushy stunt, tobacco necrosis, tobacco ringspot, tobacco mosaic and potato virus X. Within the errors of the experiment the inactivation curves appear to be exponential, and the inactivation doses increase in the order gamma-rays, X-rays, of wave-length 1·5 A., X-rays of wave-length 8·3 A., and alpha-rays.

A theory is given explaining these results and correlating the inactivation dose with the virus size. Estimates of the sizes of the viruses obtained from the radiation experiments he within the range of the sizes given by other methods, but are somewhat lower than the most probable sizes. Possible explanations of the discrepancy which are discussed are (a) the virus particle is not the molecule, in the sense of the smallest infective unit, or (b) certain structural changes in the virus molecule produced by the radiation may still leave it infective. Some of these may perhaps show themselves as mutations.

Type
Research Article
Information
Parasitology , Volume 34 , Issue 2 , July 1942 , pp. 227 - 237
Copyright
Copyright © Cambridge University Press 1942

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