Hostname: page-component-7479d7b7d-c9gpj Total loading time: 0 Render date: 2024-07-12T14:21:57.990Z Has data issue: false hasContentIssue false
  • English
  • Français

Mechanism of skin penetration by Ancylostoma tubaeforme larvae

Published online by Cambridge University Press:  06 April 2009

Bernard E. Matthews
Bernard E. Matthews
Affiliation:
Department of Zoology and Applied Entomology, Imperial College, University of London, London, S.W.7
Get access Rights & Permissions [Opens in a new window]

Extract

Skin penetration by infective Ancylostoma tubaeforme larvae has been investigated cinematographically and using in vitro techniques. The dermal tissue appears to cause little hindrance to larval migration but complete penetration through the skin from the dermal direction did not occur, although total penetration from the epidermal surface was frequently accomplished. No evidence could be found for enzymic secretions emanating from the worms under conditions that gave positive results from Necator americanus and Strongyloides fülleborni infective larvae. The results indicated that A. tubaeforme was able to penetrate without the use of enzymic secretions and an alternative, mechanical mechanism for penetration is advanced.

Type
Research Article
Information
Parasitology , Volume 70 , Issue 1 , February 1975 , pp. 25 - 38
Copyright
Copyright © Cambridge University Press 1975

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Archer, R. K., (1965). Haematological Technique for Use on Animals. Oxford: Blackwell Scientific Publications.Google Scholar
Breathnach, A. S., (1971). An Atlas of the infrastructure of the Human Skin: Development, Differentiation and Post-natal Features. Edinburgh: Churchill.Google Scholar
Bruce, J. I., Pezzlo, F., McCarty, J. E., & Yajima, Y., (1970). Migration of Schistosoma mansoni through mouse tissue. Ultrastructure of host tissue and integument of migrating larvae following cercarial penetration. American Journal of Tropical Medicine and Hygiene 19, 959–81.Google Scholar
Clegg, J. A., (1969). Skin penetration by cercariae of the bird schistosome Austrobilharzia terrigalensis: the stimulatory effect of cholesterol. Parasitology 59, 973–89.Google Scholar
Croll, N. A., (1972). Energy utilization of infective Ancylostoma tubaeforme larvae. Parasitology 64, 355–68.Google Scholar
Curtis, A. S. G., (1972). Adhesive interactions between organisms. In Functional Aspects of Parasite Surfaces (ed. Taylor, A. E. B., and Muller, R.), pp. 1–21. Oxford: Blackwell Scientific Publications.Google Scholar
Duke, B. O. L., (1971). The ecology of onchocerciasis in man and animals. In Ecology and Physiology of Parasites (ed. Fallis, A. M.), pp. 213–22. University of Toronto Press.CrossRefGoogle Scholar
Gersh, J., & Catchpole, H. R., (1949). The organization of ground substance and basement membrane and its significance in tissue injury, disease and growth. American Journal of Anatomy 85, 457–522.Google Scholar
Gordon, R. M., & Griffiths, R. B., (1952). Observations on the means by which the cercariae of Schistosoma mansoni penetrate mammalian skin, together with an account of certain morphological changes observed in newly penetrated larvae. Annals of Tropical Medicine and Parasitology 45, 227–43.Google Scholar
Jarrett, A., (1958). The structure of collagen and elastic tissue in unprocessed skin. British Journal of Dermatology 70, 343–7.Google Scholar
Jarrett, A., & Matthews, B. E., (1973). The physical nature of dermal collagen. Rheumatology and Physical Medicine, 12, 32–6.CrossRefGoogle ScholarPubMed
Jarrett, A., & Spearman, R. I. C., (1964). Histochemistry of the Skin — Psoriasis. London: English Universities Press.Google Scholar
Lee, D. L., (1972). Penetration of mammalian skin by the infective larvae of Nippostrongylus brasiliensis. Parasitology 65, 499–505.CrossRefGoogle ScholarPubMed
Lewert, R. M., Hopkins, D. R., & Mandlowitz, S., (1966). The role of calcium and magnesium ions in invasiveness of schistosome cercariae. American Journal of Tropical Medicine and Hygiene 15, 314–23.CrossRefGoogle ScholarPubMed
Lewert, R. M., & Lee, C. L., (1954). Studies on the passage of helminth larvae through host tissues. I: Histochemical studies on extracellular changes caused by penetrating larvae. II: Enzymatic activity of larvae in vitro and in vivo. Journal of Infectious Diseases 95, 13–51.CrossRefGoogle ScholarPubMed
Lewert, R. M., & Lee, C. L., (1956). Quantitative studies of the collagenase-like enzymes of cercariae of Schistosoma mansoni and the larvae of Strongyloides ratti. Journal of Infectious Diseases 99, 1–14.Google Scholar
Looss, A., (1911). The anatomy and life history of Anchylostoma duodenale Dub.: Pt. II. Cairo Records of the Egyptian School of Medicine 4, 167–607.Google Scholar
Matthews, B. E., (1972). Invasion of skin by larvae of the cat hookworm, Ancylostoma tubaeforme. Parasitology 65, 457–67.CrossRefGoogle ScholarPubMed
Matthews, B. E., & Croll, N. A., (1973). Influence of adult hookworm age on larval progeny. Transactions of the Royal Society of Tropical Medicine and Hygiene 67, 608.Google Scholar
Milleman, R. E., & Thonard, J. C., (1959). Protease activity in schistosome cercariae. Experimental Parasitology 8, 129–36.CrossRefGoogle Scholar
Smith, M. A., (1972). A collagenase-like enzyme secreted by the eggs of Schistosoma mansoni and its inhibition by a factor in serum. Project report for the degree of Bachelor of Technology in Applied Biology. Brunei University.Google Scholar
Standen, O. D., (1953). The penetration of the cercariae of Schistosoma mansoni into the skin and lymphatics of the mouse. Transactions of the Royal Society of Tropical Medicine and Hygiene 47, 292–8.CrossRefGoogle ScholarPubMed
Stirewalt, M. A., (1958). Relation of skin reaction to penetration and to the development of local resistance to entry by challenging cercariae of Schistosoma mansoni. Proceedings of the VIth International Congress on Tropical Medicine and Malaria, vol. 2, pp. 67–76.Google Scholar
Stirewalt, M. A., (1959). Chronological analysis, pattern and rate of migration of cercariae of Schistosoma mansoni in body, ear and tail skin of mice. Annals of Tropical Medicine and Parasitology 53, 400–13.CrossRefGoogle ScholarPubMed
Stirewalt, M. A., (1963). Chemical biology of secretions of larval helminths. Annals of the New York Academy of Sciences 113, 36–53.CrossRefGoogle ScholarPubMed
Stirewalt, M. A., (1966). Skin penetration mechanisms of helminths. In Biology of Parasites (ed. Soulsby, E. J. L.), pp. 41–59. New York and London: Academic Press.Google Scholar
Stirewalt, M. A., & Kruidenier, F. J., (1961). Activity of the acetabular secretory apparatus of cercariae of Schistosoma mansoni under experimental conditions. Experimental Parasitology 11, 191–211.Google Scholar
Szent-Gyöbgyi, A., (1969). Molecules, electrons and biology. Transactions of the New York Academy of Sciences, ser. II. 31, 334–40.CrossRefGoogle Scholar