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Modification of macrophage – T cell interaction during infection of mice with Mesocestoides corti (Cestoda)

Published online by Cambridge University Press:  06 April 2009

S. K. Kadian ,
J. B. Dixon ,
J. R. Green ,
S.D. Carter  and
P. Jenkins
S. K. Kadian
Affiliation:
Departments of Veterinary Pathology, University of Liverpool, Liverpool L69 3BX
J. B. Dixon
Affiliation:
Departments of Veterinary Pathology, University of Liverpool, Liverpool L69 3BX
J. R. Green
Affiliation:
Departments of Statistics and Computational Mathematics, University of Liverpool, Liverpool L69 3BX
S.D. Carter
Affiliation:
Departments of Veterinary Pathology, University of Liverpool, Liverpool L69 3BX
P. Jenkins
Affiliation:
Departments of Veterinary Pathology, University of Liverpool, Liverpool L69 3BX
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Extract

Peritoneal macrophages from Mesocestoides corti-infected mice showed a marked and progressive loss of ability to act as accessory cells for syngeneic Con A-stimulated mesenteric lymph node lymphocytes. The same effect on the macrophages could be induced by intraperitoneal injection of M. corti culture supernatant, despite a concurrent increase in numbers of peritoneal adhesive macrophages. The findings are used to compare and contrast the known immunomodulatory effects of M. corti and taeniid metacestodes, the latter differing chiefly in their potential for modifying T-cell as well as macrophage behaviour.

Keywords

Mesocestoides cortiimmunoregulationmacrophageaccessory cellT cellEchinococcus spp
Type
Research Article
Information
Parasitology , Volume 109 , Issue 5 , December 1994 , pp. 591 - 597
Copyright
Copyright © Cambridge University Press 1994

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References

REFERENCES

Allan, D., Jenkins, P., Connor, R. J. & Dixon, J. B. (1981). A study of immunoregulation of BALB/c mice by Echinococcus granulosus equinus during prolonged infection. Parasite Immunology 3, 137–42.CrossRefGoogle ScholarPubMed
Cook, R. M., Ashworth, R. F. & Chernin, J. (1988). Cytotoxic activity of rat granulocytes against Mesocestoides corti. Parasite Immunology 10, 97–109.CrossRefGoogle ScholarPubMed
Cox, D. A., Dixon, J. B. & Marshall-Clarke, S. (1986). Transformation induced by Echinococcus granulosus protoscoleces in unprimed murine spleen cells: identity and MHC restriction of participating cell types. Immunology 57, 461–6.Google ScholarPubMed
Damian, R. T. (1987). The exploitation of host immune response by parasites. Journal of Parasitology 73, 3–13.CrossRefGoogle ScholarPubMed
Del Pozo, V., De-Andres, B., Martin, E., Cardaba, B., Fernandez, J. C., Gallardo, S., Tramon, P., Leyva Cobian, F., Palomino, P. & ahoz, C. (1992). Eosinophil as antigen presenting cell: activation of T-cell clones and T-cell hybridoma by eosinophils after antigen processing. European Journal of Immunology 22, 1919–25.CrossRefGoogle ScholarPubMed
Ellis, M. E., Sinner, W., Ali, M. A. & Qadri, S. M. H. (1991). Echinococcal diseases and mycobacterial infection. Annals of Tropical Medicine and Parasitology 85, 243–51.CrossRefGoogle ScholarPubMed
Goldstein, A. (1964). Biostatistics, An Introductory Text. New York: Macmillan Co.Google Scholar
Jenkins, P., Dixon, J. B., Rakha, N. K. & Carter, S. D. (1990). Regulation of macrophage-mediated larvicidal activity in Echinococcus granulosus and Mesocestoides corti (Cestoda) infection in mice. Parasitology 100, 309–15.CrossRefGoogle ScholarPubMed
Jenkins, P., Dixon, J. B., Haywood, S., Rakha, N. K. & Carter, S. D. (1991). Differential regulation of murine Mesocestoides corti infection by bacterial lipopolysaccharide and interferon-γ. Parasitology 102, 125–32.CrossRefGoogle ScholarPubMed
Jenkins, P., Spiers, S., Dixon, J. B., Carter, S. D. & May, S. (1992). The effects of tumour necrosis factor on host–parasite relations in murine Mesocestoides corti (Cestoda) infection. Parasitology 105, 453–9.CrossRefGoogle ScholarPubMed
Judson, D. G., Dixon, J. B., Skerritt, G. C. & Stallbaumer, M. (1984). Mitogenic effect of Coenurus cerebralis cyst fluid. Research in Veterinary Science 37, 128.CrossRefGoogle ScholarPubMed
Judson, D. G., Dixon, J. B. & Skerritt, G. C. (1987). Occurrence and biochemical characteristics of cestode lymphocyte mitogens. Parasitology 94, 151–60.CrossRefGoogle ScholarPubMed
Leid, R. W., Suquet, C. M. & Tanigoshi, L. (1987). Parasite defence mechanisms for evasion of host attack; a review. Veterinary Parasitology 25, 147–62.CrossRefGoogle ScholarPubMed
Mitchell, G. F. & Handman, E. (1977). Studies on immune responses to larval cestodes in mice: a simple mechanism of non-specific immunosuppression in Mesocestoides corti-infected mice. Australian Journal of Experimental Biological and Medical Science 55, 615–22.CrossRefGoogle ScholarPubMed
Rakha, N. K., Dixon, J. B., Skerritt, G. C., Carter, S. D., Jenkins, P. & Marshall-Clarke, S. (1991 a). Lymphoreticular responses to metacestodes: Taenia multiceps (Cestoda) can modify interaction between accessory cells and responder cells during lymphocyte activation. Parasitology 102, 133–40.CrossRefGoogle ScholarPubMed
Rakha, N. K., Dixon, J. B., Jenkins, P., Carter, S. D., Skerritt, G. C. & Marshall-Clarke, S. (1991 b). Modification of cellular immunity by Taenia multiceps (Cestoda): accessory macrophages and CD4 + lymphocytes are affected by two different coenurus factors. Parasitology 103, 139–97.CrossRefGoogle ScholarPubMed
Rakha, N. K., Dixon, J. B., Carter, S. D., Craig, P. S., Jenkins, P. & Folkard, S. (1991 c). Echinococcus multilocularis antigens modify accessory cell function of macrophages. Immunology 74, 652–6.Google ScholarPubMed
Rakha, N. K., Dixon, J. B., Skerritt, G. C., Carter, S. D. & Jenkins, P. (1992). Modification of accessory activity of sheep monocytes in vitro by a coenurus antigen from Taenia multiceps. Veterinary Immunology and Immunopathology 30, 293–304.CrossRefGoogle ScholarPubMed
Riley, E. M., Dixon, J. B., Jenkins, P. & Ross, G. (1986). Echinococcus granulosus infection in mice: host responses during primary and secondary infection. Parasitology 92, 391–403.CrossRefGoogle ScholarPubMed
Ross, G., Dixon, J. B. & Veevers, A. (1987). Variation in the lymphocyte transformation assay. Slope analysis of cell dose-response curves. Journal of Immunological Methods 98, 189–93.CrossRefGoogle ScholarPubMed
Unanue, E. R. & Allen, P. M. (1987). The basis for the immunoregulatory role of macrophages and other accessory cells. Science 236, 551–7.CrossRefGoogle ScholarPubMed