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Nematode neuropeptide receptors and their development as anthelmintic screens

Published online by Cambridge University Press:  29 March 2006

K. GREENWOOD ,
T. WILLIAMS  and
T. GEARY
K. GREENWOOD
Affiliation:
Pfizer Animal Health, Ramsgate Road, Sandwich, Kent CT13 9NJ
T. WILLIAMS
Affiliation:
Pfizer Animal Health, Ramsgate Road, Sandwich, Kent CT13 9NJ
T. GEARY
Affiliation:
Institute of Parasitology, McGill University, 21 111 Lakeshore Road, Ste-Anne de Bellevue, H9X 3V9, PQ, Canada
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Abstract

This review addresses the potential use of neuropeptide receptors for the discovery of anthelmintic agents, and particularly for the identification of non-peptide ligands. It outlines which nematode neuropeptides are known and have been characterized, the published information on drug discovery around these targets, information about existing high- and low-throughput screening systems and finally the likely safety of neuropeptide mimetics.

Keywords

NematodesanthelminticdiscoveryFMRFamideG protein-coupled receptors
Type
Research Article
Information
Parasitology , Volume 131 , Supplement S1: Parasite neuromusculature and its utility as a drug target , October 2005 , pp. S169 - S177
Copyright
2005 Cambridge University Press

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