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Observations on the course of Eperythrozoon coccoides infections in mice, and the sensitivity of the parasite to external agents

Published online by Cambridge University Press:  06 April 2009

June P. Thurston
June P. Thurston
Affiliation:
Molteno Institute, University of Cambridge
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Extract

Non-splenectomized mice developed acute infections of Eperythrozoon coccoides after inoculation, but were then immune to re-infection. Splenectomy evoked acute infections that were heavier and longer in duration than the primary infection; during this phase, the parasites doubled in number in about 5 hr. The presence of splenic tissue transplanted subcutaneously did not prevent this evocation by splenectomy.

The number of eperythrozoa decreased rapidly after the peak of infection had been reached, but no immune factor was detected in the blood. No immune factor or infection was transmitted from mother to offspring through the milk.

Citrated blood remained infective for 11 days at 3° C., for 17 hr. at 16–17·7°C. and for 3 hr. at 37° C. It was not infective after 24 hr. at either 24° C. or 16–17·7°C., or after 5 hr. at 37° C. Parasitized blood was not infective after drying.

Citrated blood was infective to mice when given by mouth, but was not infective when applied externally. Urine and faeces were non-infective.

Eperythrozoa remained infective when infected blood was diluted with twice its volume of water and left for 24 hr. at 3° C. Phenol, 0·5%, rendered citrated blood non-infective in 1 hr. Neoarsphenamine, 0·1%, reduced the infectivity of citrated blood in 16 hr., and rendered it non-infective in 26 hr.

Cortisone did not affect the course of infection of E. coccoides in mice when given subcutaneously, 1·0 mg. per 20 g. mouse, once daily for 6–9 days.

Concurrent infection with Plasmodium berghei evoked relapses of E. coccoides during the terminal stages of the P. berghei infection.

Type
Research Article
Information
Parasitology , Volume 45 , Issue 1-2 , May 1955 , pp. 141 - 151
Copyright
Copyright © Cambridge University Press 1955

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References

REFERENCES

Bruynoghe, R. & Vassiliadis, P. C. (1929 a). Transmission des eperythrozoaires de la souris. C.R. Soc. Biol., Paris, 102, 939.Google Scholar
Bruynoghe, R. & Vassiliadis, P. C. (1929 b). Contribution à l'étude des eperythrozoaires coccoïdes. Ann. Parasit. hum. comp. 7, 353.CrossRefGoogle Scholar
Dinger, J. E. (1929). Näheres über das Eperythrozoon coccoides. Zbl. Bakt. (1 Abt. Orig.), 113, 503.Google Scholar
Eliot, C. P. (1936). The insect vector for the natural transmission of Eperythrozoon coccoides in mice. Science, 84, 397.CrossRefGoogle ScholarPubMed
Eliot, C. P. & Ford, W. W. (1930). Eperythrozoon coccoides in mice. Amer. J. Hyg. 12, 677.Google Scholar
Findlay, G. M. & Howard, E. M. (1952). Cortisone and Plasmodium berghei infection in mice. Nature, Lond., 169, 547.CrossRefGoogle ScholarPubMed
Findlay, G. M., Klieneberger, E., Maccallum, F. O. & Mackenzie, R. D. (1939). Eperythrozoon in the blood of mice and its possible relationship to pleuropneumonia-like organisms. Trans. R. Soc. Trap. Med. Hyg. 33, 6.Google Scholar
Marmorston, J. (1935). Effect of splenectomy on a latent infection, Eperythrozoon coccoides, in white mice. J. Infect. Dis. 56, 142.CrossRefGoogle Scholar
Mayer, M., Borchardt, W. & Kikuth, W. (1927). Die durch Miltzexstirpation auslösbare infektiöse Rattenanämie. Arch. Schiffs-u. Tropenhyg. 31, 291.Google Scholar
Niven, J. S. F., Gledhill, A. W., Dick, G. W. A. & Andrewes, C. H. (1952). Further light on mouse hepatitis. Lancet, ii, 1061.CrossRefGoogle Scholar
Roberts, O. J. (1954). The effect of cortisone on Plasmodium berghei infections. Parasitology, 44, 58.CrossRefGoogle ScholarPubMed
Rosenthal, L. & Zohman, B. L. (1931). Bartonella anemia in non-splenectomized rats. Arch. Path. 12, 405.Google Scholar
Schilling, V. (1928). Eperythrozoon coccoides, eine neue durch Splenektomie aktivierbare Dauerinfektion der weissen Maus. Klin. Wschr. p. 1853.CrossRefGoogle Scholar
Schmidt, L. H. & Squires, W. L. (1951). The influence of cortisone on primate malaria. J. Exp. Med. 94, 501.CrossRefGoogle ScholarPubMed
Schneider, J. (1953). Cortisone et paludisme, action nulle dans les essais sur PI. berghei, PI. gallinaceum et PI. vivax. Bull. Soc. Pat. exot. 46, 1016.Google Scholar
Splitter, E. J. (1950). Eperythrozoon suis, the etiologic agent of ictero-anemia or an Anaplasmosis-like disease in swine. Amer. J. Vet. Res. 11, 324.Google ScholarPubMed
Splitter, E. J. (1952). Eperythrozoonosis in swine—Filtration studies. Amer. J. Vet. Res. 13, 290.Google ScholarPubMed
Thurston, J. P. (1953). The chemotherapy of Eperythrozoon coccoides (Schilling, 1928). Parasitology, 43, 170.CrossRefGoogle ScholarPubMed
Thurston, J. P. (1954). Anaemia in mice caused by Eperythrozoon coccoides (Schilling, 1928). Parasitology, 44, 81.CrossRefGoogle ScholarPubMed
Weinman, D. (1935). Les parasites érythrocytaires révélés par la splénectomie: bartonetta et epérythrozoon. Paris: Amédée Legrand.Google Scholar
Weinman, D. (1944). Infectious anemias due to Bartonella and related blood parasites. Trans. Amer. Phil. Soc., N.S., 33, pt. 3, 243.CrossRefGoogle Scholar