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Progress towards understanding the immunobiology of Theileria parasites

Published online by Cambridge University Press:  20 August 2009

W. IVAN MORRISON
W. IVAN MORRISON*
Affiliation:
The Roslin Institute, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, UK
*
*Corresponding author: Tel: (0)131 650 6216. E-mail: ivan.morrison@ed.ac.uk
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Summary

The pathogenic Theileria species Theileria parva and T. annulata infect bovine leukocytes and erythrocytes causing acute, often fatal lymphoproliferative diseases in cattle. The parasites are of interest not only because of their economic importance as pathogens, but also because of their unique ability to transform the leukocytes they infect. The latter property allows parasitized leukocytes to be cultured as continuously growing cell lines in vitro, thus providing an amenable in vitro system to study the parasite/host cell relationship and parasite-specific cellular immune responses. This paper summarizes important advances in knowledge of the immunobiology of these parasites over the last 40 years, focusing particularly on areas of relevance to vaccination.

Keywords

Theileriacell biologyCD8 T cellantigenic diversityimmunodominancevaccination
Type
Research Article
Information
Parasitology , Volume 136 , Special Issue 12: Special Centenary Issue – Parasitology 1908–2008 , October 2009 , pp. 1415 - 1426
Copyright
Copyright © Cambridge University Press 2009

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