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Temporal changes in Trichuris trichiura infection intensity and serum isotype responses in children

Published online by Cambridge University Press:  06 April 2009

C. S. Needham ,
J. E. Lillywhite ,
J. M. Didier ,
A. E. Bianco  and
D. A. P. Bundy
C. S. Needham
Affiliation:
Wellcome Research Centre, Department of Biology, Imperial College, Prince Consort Road, London SW7 2BB, UK
J. E. Lillywhite
Affiliation:
Wellcome Research Centre, Department of Biology, Imperial College, Prince Consort Road, London SW7 2BB, UK
J. M. Didier
Affiliation:
Parasite Epidemiology Project, University Centre, P.O. Box 306, Castries, St Lucia, West Indies
A. E. Bianco
Affiliation:
Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
D. A. P. Bundy
Affiliation:
Wellcome Research Centre, Department of Biology, Imperial College, Prince Consort Road, London SW7 2BB, UK
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Summary

The present study describes Trichuris trichiura infections in a cohort of children over a period of approximately 5 years, and examines the relationships between changes in infection intensity and changes in parasite-specific isotype responses (measured by ELISA). The decrease in mean infection intensity with time was mirrored by time-dependent changes in IgG subclass responses, with IgA and IgE levels remaining relatively constant in the cohort. At the individual level, changes in infection intensity between the initial and final time-points correlated positively and significantly with changes in all isotype levels with the exception of IgA.

Keywords

timeTrichuris trichiuraisotype responseslongitudinal studychildren
Type
Research Article
Information
Parasitology , Volume 109 , Issue 2 , August 1994 , pp. 197 - 200
Copyright
Copyright © Cambridge University Press 1994

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References

REFERENCES

Bundy, D. A. P. & Medley, G. F. (1992). Immunoepidemiology of human geohelminths: ecological and immunological determinants of worm burden. Parasitology 104, S105–19.CrossRefGoogle ScholarPubMed
Lillywhite, J. E., Bundy, D. A. P., Didier, J. M., Cooper, E. S. & Bianco, A. E. (1991). The humoral immune response in human infection with the whipworm Trichuris trichiura. Parasite Immunology 13, 491–507.CrossRefGoogle ScholarPubMed
Maizels, R. M., Bundy, D. A. P., Selkirk, M. E., Smith, D. F. & Anderson, R. M. (1993). Immunological modulation and evasion by helminth parasites in human populations. Nature, London 365, 797–805.CrossRefGoogle ScholarPubMed
Michael, E. & Bundy, D. A. P. (1992). Nutrition, immunity and helminth infection: effect of dietary protein on the dynamics of the primary antibody response to Trichuris muris (Nematoda) in CBA/Ca mice. Parasite Immunology 14, 169–83.CrossRefGoogle ScholarPubMed
Needham, C. S., Bundy, D. A. P., Lillywhite, J. E., Didier, J. M., Simmons, I. & Bianco, A. E. (1992). The relationship between Trichuris trichiura transmission intensity and the age-profiles of parasite-specific antibody isotypes in two endemic communities. Parasitology 105, 273–83.CrossRefGoogle ScholarPubMed
Needham, C. S. & Lillywhite, J. E. (1994). Immunological correlates with patterns of Trichuris infection. Transactions of the Royal Society of Tropical Medicine and Hygiene (in the Press).CrossRefGoogle ScholarPubMed
Needham, C. S., Lillywhite, J. E., Didier, J. M. & Bundy, D. A. P. (1994). Serum isotype responses after treatment in human trichuriasis. Transactions of the Royal Society of Tropical Medicine and Hygiene (in the Press).CrossRefGoogle ScholarPubMed
Pritchard, D. I., Walsh, E. A., Quinnell, R. J., Raiko, A., Edmonds, P. & Keymer, A. E. (1992). Isotypic variation in antibody responses in a community in Papua New Guinea to larval and adult antigens during infection, and following reinfection, with the hookworm Necator americanus. Parasite Immunology 14, 617–31.CrossRefGoogle Scholar
Woolhouse, M. E. J. (1992). Immunoepidemiology of intestinal helminths: patterns and process. Parasitology Today 8, 111.CrossRefGoogle ScholarPubMed