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The Treatment of Surra in Horses by Means of Arsenic and its Derivatives

Published online by Cambridge University Press:  06 April 2009

J. D. E Holmes
J. D. E Holmes
Affiliation:
Imperial Bacteriologist to the Government of India.
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Extract

The value of arsenic in the treatment of trypanosomiasis is no new discovery.

Evans (1880), who described the first pathogenic trypanosome, recommended the administration of arsenic. Lingard (1899), for many years, investigated surra in India and treated twenty-one horses suffering from that disease with arsenious acid. One horse survived. His system of treatment was, the administration of arsenic in the form of Fowler's solution, commencing with 5 grains, twice daily and gradually increasing to 10 grains. Treatment extended over several months; the total amount of arsenic given, in some instances, amounted to over 2,000 grains. During the period of treatment intermissions of 30 to 50 days were recorded, but all the animals, with one exception, finally succumbed to the disease. Bruce (1897 and 1903), treating nagana in Zululand, gave 6 to 12 grains of arsenic in form of arsenite of soda to horses and asses suffering from that disease. Trypanosomes remained absent during the period of treatment, but reappeared immediately treatment ceased. Trélut (1907) claims to have cured cases of dourine by the daily administration of 3 to 6 grammes of arsenious acid. Archangeliky and Novikoff (1907) also record cases of dourine cured by them with arsenite of sodium and cacodylic acid. Marchal (1903) stated that he cured five stallions suffering from dourine by subcutaneous injections of 1 gramme of cacodylate of soda. Loeffler and Ruehs (1908) record a number of successful experiments on animals affected with nagana, which they treated with a solution of arsenious acid. They consider this solution to be a specific cure and a prophylactie for nagana. Laveran and Thiroux (1907–8) repeated these experiments and came to conclusions different form those of Loeffler and Ruehs.

Type
Research Article
Information
Parasitology , Volume 3 , Issue 1 , April 1910 , pp. 73 - 107
Copyright
Copyright © Cambridge University Press 1910

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References

REFERENCES

Archangeliky, and Novikoff, (1907). Quoted from Trypanosomes and Trypanosomiasis, by Laveran and Mesnil (translated by Nabarro), p. 338.Google Scholar
Breinl, A. and Nierenstein, M. (1909). Zum Mechanismus der Atoxylwirkung. Zeitschr. f. Immunitatsforsch. u. exper. Therapie, Vol. i. pp. 620–632.Google Scholar
Breinl, A. and Salvin-Moore, J. E. (1908). The cytology of the Trypanosomes. Part I. Ann. Trop. Med. and Parasitol. Vol. i. pp. 441–480.Google Scholar
Broden, A. and Rodhain, J. (v. 1909). Traitement de la Trypanosomiase humaine. Arch. f. Schiffs-u. Tropen-Hygiene, pp. 269–283.Google Scholar
SirBruce, D. (1897). Further report on Nagana in Zuhdand, and (1903) Appendix to further report on Nagana in Zululand.Google Scholar
Ehrlich, P. (1908). Ueber den jetzigen Stand der Chemo-therapie. Ber. d. deutschen chem. Oesellsch., xxxii. Heft. I.Google Scholar
Ehrlich, P. (1908). Ueber moderne Chemo-therapie. Verhandl. d. Deutschen Dermatolog. Gesellsch., x. Kongress, pp. 52–70.Google Scholar
Evans, G. (1880). Report on Surra, Punjab Government, Military Department.Google Scholar
Friedberger, E. (09. 1908). Ueber die Behandlung der experimentellen Nagana mit Mischungen von Atoxyl und Thioglykolsäure. Berlin, klin. Wochenschr., No. 38.Google Scholar
Holmes, J. D. E. (1909). Investigation of an outbreak of Horse Surra, with result of treatment with Atoxyl, Tartar emetic, Mercury and other drugs. Report of Research work of Imperial Bacteriological Laboratory, Muktesar (1908–09).Google Scholar
Holmes, J. D. E. (1904). Evolution of the Trypanosoma evansi. Journ. Comp. Pathol, and Therapeutics, Vol. xvii. pp. 210–214.CrossRefGoogle Scholar
Kaufmann, (1901). Traité de Thérapeutique et de Matière Médicate Vétérinaire, p. 442.Google Scholar
Laveran, A. and Thiroux, A. (1907). L'emploi de l'acide arsenieux est il preventif des Trypanosomiasis. Compt. Rend. Acad. Sci., cxlv. p. 561.Google Scholar
Laveran, A. and Thiroux, A. (1908). Recherches sur le traitement des Trypanosomiasis. Ann. Inst. Pasteur, xx. pp. 96–131.Google Scholar
Law, (1900) Veterinary Medicine, Vol. ii. p. 270.Google Scholar
Levaditi, C. and Yamanouchi, T. (1908). Mécanisme d'action de l'Atoxyl dans les Trypanosomiasis. Compt. Rend. Soc. de Biol., lxv. p. 23.Google Scholar
Lingard, A. (1899). Report on Surra in Equines. Bombay (Vol. ii. Part I).Google Scholar
Loeffler, E. and Ruehs, K. (1907). Die Heilung der experimentellen Nagana. Deutsche med. Woclienschr., No. 34.CrossRefGoogle Scholar
Loeffler, E. and Ruehs, K. (1907). Die Heilung der experimentellen Nagana. Also Deutsche med. Woclienschr. 1908, No. 1.CrossRefGoogle Scholar
Loeffler, E. and Ruehs, K. and Walter, E. (1908). Die Heilung der experimentellen Nagana. Deutsche med. Wochenschr., No. 34.Google Scholar
Marchal, E. (1903). Le Traitement de la Dourine par les Cacodylates. Rec. de Méd. Vétér., x. pp. 230–232.Google Scholar
Martin, G., Leboeuf, and Ringenbach, (06. 1909). Sur le traitement de la Trypano- some humaine. Bull. Soc. de Pathol. Exotique, pp. 308–313.Google Scholar
Mesnil, F., Nicolle, M. and Aubert, P. (1907). Recherches sur le traitement des infections experimentales à Trypanosoma gambiense. Ann. Inst. Pasteur, xxi. pp. 1–19.Google Scholar
Moore, B., Nierenstein, M. and Todd, J. L. (1907). On the treatment of Trypanosomiasis by Atoxyl and a Mercuric Salt. Biochem. Journ., ii. Nos. 5 and 6, p. 300.CrossRefGoogle Scholar
Nierenstein, M. (1908—1909). Comparative Chemo-therapeutical study of Atoxyl and Trypanocides. Ann. Trop. Med. and Parasitol., Part I. No. 3, pp. 249–255, Part II. No. 4, pp. 323–327.CrossRefGoogle Scholar
Tendron, E. (1909). Recherches sur Félimination de l'arsenic après injections sous-cutanées d'atoxyl par le dosage de l'arsenic dans les urines et les féces. Bull. Soc. de Pathol. Exotique, marz n. pp. 140–145.Google Scholar
Thiroux, A. and Teppaz, L. (1909). Traitement de la Baleri chez le cheval par l'orpiment. Compt. Rend. Acad. d. Sci., cxlvii. pp. 115, 116.Google Scholar
Thiroux, A. and Teppaz, L. (1909). Traitement des trypanosomiasis chez les chevaux par l'orpiment seul ou associé à l'Atoxyl. Ann. Inst. Pasteur, xxiii. pp. 240–252.Google Scholar
Thiroux, A. and Teppaz, L. (1909). Traitement des trypanosomiasis chez les chevaux par l'orpiment seul ou associé à l'Atoxyl. Ann. Inst. Pasteur pp. 426–429.Google Scholar
Thomas, H. W. (1905). The Experimental treatment of Trypanosomiasis in Animals. Proc. Roy. Soc., B., Vol. lxxvi. pp. 589–591.Google Scholar
Trélut, (1907). Quoted from Trypanosomes and Trypanosomiasis, by Laveran and Mesnil (translated by Nabarro), p. 338.Google Scholar
Uhlenhuth, and Woithe, (1908). Experimentelle Untersuchungen über Dourine mit besonderer Berücksichtigung der Atoxylbehandlung. Arb. a. d. Kaiserl. Gesumdkeitsamte, xxix. pp. 403–451.Google Scholar
Wedemann, W. (1901). Toxikologische Versuche mit Atoxyl an zahmen Ratten. Arb. a. d. Kaiserl. Gesundheitsamte, xxviii. p. 585.Google Scholar