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Trypanosoma evansi infection impairs memory, increases anxiety behaviour and alters neurochemical parameters in rats

Published online by Cambridge University Press:  21 August 2013

PATRÍCIA WOLKMER ,
FRANCINE C. PAIM ,
CÁSSIA B. DA SILVA ,
BIBIANA M. GAI ,
FABIANO B. CARVALHO ,
ANA CRISTINA G. DA SOUZA ,
MICHELLE M. DA ROSA ,
ALEKSANDRO S. DA SILVA ,
PAULA R. PEREIRA  and
SONIA T. A. LOPES
...Show all authors
PATRÍCIA WOLKMER*
Affiliation:
Department of Chemistry, Universidade Federal de Santa Maria, Brazil Department of Small Animals, Universidade Federal de Santa Maria, Brazil
FRANCINE C. PAIM
Affiliation:
Department of Small Animals, Universidade Federal de Santa Maria, Brazil
CÁSSIA B. DA SILVA
Affiliation:
Department of Small Animals, Universidade Federal de Santa Maria, Brazil
BIBIANA M. GAI
Affiliation:
Department of Chemistry, Universidade Federal de Santa Maria, Brazil
FABIANO B. CARVALHO
Affiliation:
Department of Chemistry, Universidade Federal de Santa Maria, Brazil
ANA CRISTINA G. DA SOUZA
Affiliation:
Department of Chemistry, Universidade Federal de Santa Maria, Brazil
MICHELLE M. DA ROSA
Affiliation:
Department of Chemistry, Universidade Federal de Santa Maria, Brazil
ALEKSANDRO S. DA SILVA
Affiliation:
Department of Microbiology and Parasitology, Universidade Federal de Santa Maria, Brazil
PAULA R. PEREIRA
Affiliation:
Department of Small Animals, Universidade Federal de Santa Maria, Brazil
SONIA T. A. LOPES
Affiliation:
Department of Small Animals, Universidade Federal de Santa Maria, Brazil
CRISTINA W. NOGUEIRA
Affiliation:
Department of Chemistry, Universidade Federal de Santa Maria, Brazil
MARIBEL A. RUBIN
Affiliation:
Department of Chemistry, Universidade Federal de Santa Maria, Brazil
SILVIA G. MONTEIRO
Affiliation:
Department of Microbiology and Parasitology, Universidade Federal de Santa Maria, Brazil
CINTHIA M. MAZZANTI
Affiliation:
Department of Chemistry, Universidade Federal de Santa Maria, Brazil Department of Small Animals, Universidade Federal de Santa Maria, Brazil
*
*Corresponding author: Departamento de Pequenos Animais da UFSM, Universidade Federal de Santa Maria, Av Roraima, Campus Universitário, 97105-900, Hospital Veterinário, Sala 103, Santa Maria – RS, Brasil. E-mail: patiwol@hotmail.com
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Summary

The aim of this study was to investigate neurochemical and enzymatic changes in rats infected with Trypanosoma evansi, and their interference in the cognitive parameters. Behavioural assessment (assessment of cognitive performance), evaluation of cerebral L-[3H]glutamate uptake, acetylcholinesterase (AChE) activity and Ca+2 and Na+, K+-ATPase activity were evaluated at 5 and 30 days post infection (dpi). This study demonstrates a cognitive impairment in rats infected with T. evansi. At 5 dpi memory deficit was demonstrated by an inhibitory avoidance test. With the chronicity of the disease (30 dpi) animals showed anxiety symptoms. It is possible the inhibition of cerebral Na+, K+-ATPase activity, AChE and synaptosomal glutamate uptake are involved in cognitive impairment in infected rats by T. evansi. The understanding of cerebral host–parasite relationship may shed some light on the cryptic symptoms of animals and possibly human infection where patients often present with other central nervous system (CNS) disorders.

Keywords

TrypanosomesCa+2 ATPaseNa+K+ ATPasecognitive dysfunctionmemoryanxietyglutamate uptake
Type
Research Article
Information
Parasitology , Volume 140 , Issue 11 , September 2013 , pp. 1432 - 1441
Copyright
Copyright © Cambridge University Press 2013 

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