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Analysis of worm burdens in experimental schistosomiasis

Published online by Cambridge University Press:  06 April 2009

A. J. C. Fulford  and
F. Yeang
A. J. C. Fulford
Affiliation:
Molteno Laboratories of Parasitology, Tennis Court Road, Cambridge CB2 1QP
F. Yeang
Affiliation:
Department of Parasitology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA
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Summary

The techniques of generalized linear modelling were applied to worm burdens of 2268 mice artificially infected with Schistosoma mansoni and treated with oxamniquine and/or praziquantel. Models which maximized the Poisson likelihood were shown to be superior to those assuming either a log Normal or negative binomial error structure. Use of the models to calculate and compare ED values of 8 strains of S. mansoni, detect abnormal dose response and synergism and to pool data from several experiments is illustrated.

Type
Research Article
Information
Parasitology , Volume 97 , Issue 2 , October 1988 , pp. 303 - 315
Copyright
Copyright © Cambridge University Press 1988

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