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The anthelmintic effects of the ethanol extract of Terminalia catappa L. leaves against the ruminant gut parasite, Fischoederius cobboldi

Published online by Cambridge University Press:  01 February 2016

PANAT ANURACPREEDA ,
KANOKWAN CHANKAEW ,
PANUPONG PUTTARAK ,
PREEYAPORN KOEDRITH ,
RUNGLAWAN CHAWENGKIRTTIKUL ,
BUSABA PANYARACHUN ,
ARIN NGAMNIYOM ,
SUMALEE CHANCHAI  and
PRASERT SOBHON
PANAT ANURACPREEDA*
Affiliation:
Division of Agricultural Science, Mahidol University, Kanchanaburi Campus, Saiyok, Kanchanaburi 71150, Thailand Department of Anatomy, Faculty of Science, Mahidol University, Rama VI Road, Bangkok 10400, Thailand
KANOKWAN CHANKAEW
Affiliation:
Division of Agricultural Science, Mahidol University, Kanchanaburi Campus, Saiyok, Kanchanaburi 71150, Thailand
PANUPONG PUTTARAK
Affiliation:
Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat-Yai, Songkhla 90112, Thailand
PREEYAPORN KOEDRITH
Affiliation:
Faculty of Environment and Resource Studies, Mahidol University, Phuttamonthon District, NakhonPathom 73170, Thailand
RUNGLAWAN CHAWENGKIRTTIKUL
Affiliation:
Department of Microbiology, Faculty of Science, Mahidol University, Rama VI Road, Bangkok 10400, Thailand
BUSABA PANYARACHUN
Affiliation:
Department of Anatomy, Faculty of Medicine, Srinakharinwirot University, Sukhumvit 23, Klongtoey Wattana, Bangkok 10110, Thailand
ARIN NGAMNIYOM
Affiliation:
Faculty of Environmental Culture and Ecotourism, Srinakharinwirot University, Sukhumvit 23, Klongtoey Wattana, Bangkok 10110, Thailand
SUMALEE CHANCHAI
Affiliation:
Department of Anatomy, Faculty of Science, Mahidol University, Rama VI Road, Bangkok 10400, Thailand
PRASERT SOBHON
Affiliation:
Department of Anatomy, Faculty of Science, Mahidol University, Rama VI Road, Bangkok 10400, Thailand
*
*Corresponding author: Division of Agricultural Science, Mahidol University, Kanchanaburi Campus, Saiyok, Kanchanaburi 71150, Thailand. E-mail: Panat1@yahoo.com, panat.anu@mahidol.ac.th
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Summary

Presently, no effective anthelmintic drugs have been used to treat and control paramphistomosis, a severe disease of ruminants. In this study, we have investigated the in vitro anthelmintic effect of the leaves of Terminalia catappa L. crude extract (TcCE) and albendazole (ABZ) on adult Fischoederius cobboldi after incubating the flukes in RPMI-1640 medium containing the TcCE at various doses and times. The TcCE-treated flukes at all dosages exhibited rapid decrease of motility, and the relative motility (RM) values were decreased sharply from start to 3 h. Worms were killed after 6 and 12 h of treatment with 1000, 1500 and 2000 µg mL−1 as well as 500 µg mL−1 of TcCE, respectively. By light microscopy examination, the flukes exhibited the earliest alteration in a limited area of the tegument. At scanning electron microscopy level, the flukes’ tegument showed similar sequence of morphological alterations after treatment with ABZ and TcCE that consisted of swelling of ridges and folds, followed by blebbing and rupturing of the blebs, leading to the erosion, lesion and disruption of the tegument. Hence, in vivo studies should be performed to examine whether the TcCE may serve as a powerful anthelmintic drug for treatment of paramphistomosis.

Keywords

Fischoederius cobboldiTerminalia catappa L.anthelmintic drugmotilitysurvivaltegumentlight microscopyscanning electron microscopy
Type
Research Article
Information
Parasitology , Volume 143 , Issue 4 , April 2016 , pp. 421 - 433
Copyright
Copyright © Cambridge University Press 2016 

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