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Ascaris egg profiles in human faeces: biological and epidemiological implications

Published online by Cambridge University Press:  09 October 2003

W. PENG ,
X. ZHOU  and
R. B. GASSER
W. PENG
Affiliation:
Jiangxi Medical Science Research Institute, 461 Bayi Road, Nanchang 330006, P. R. China Department of Veterinary Science, The University of Melbourne, 250 Princes Highway, Werribee, Victoria 3030, Australia
X. ZHOU
Affiliation:
Department of Parasitology, Jiangxi Medical College, 603 Bayi Road, Nanchang 330006, P. R. China
R. B. GASSER
Affiliation:
Department of Veterinary Science, The University of Melbourne, 250 Princes Highway, Werribee, Victoria 3030, Australia
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Abstract

Since 2 morphological forms (fertilized and unfertilized) of egg can be produced by Ascaris, infected humans can release in their faeces fertilized eggs only (FEO), unfertilized eggs only (UEO) or both fertilized and unfertilized eggs (FUE) (designated herein as the 3 different egg profiles). Epidemiologically, fertilized eggs are of significance as they enable effective transmission of the parasite. This study, for the first time, characterizes the Ascaris egg profiles in human faeces in an endemic region of China, explores possible host- and parasite-factors related to these profiles, and discusses the biological and epidemiological implications of the findings. The 3 egg profiles were recorded throughout the study period of 2 years, and the overall percentages of people with FEO, FUE and UEO profiles were ~41–47%, 32–42% and 17–21%, respectively. The overall number of unfertilized eggs for the entire population accounted for ~6–9% of all eggs excreted. The different Ascaris egg profiles showed no correlation to host gender, but they did relate to age and worm burden of the host and to the sex ratio and developmental status of the parasite. While an annual universal anthelmintic treatment resulted in some fluctuation in the values of individual egg profiles, the general features of these profiles remained similar throughout the study period. The findings of this study should have significant implications for understanding transmission patterns of Ascaris and for the implementation of control measures against ascariasis in endemic regions.

Keywords

Ascarisfertilized eggsunfertilized eggsepidemiologyChina
Type
Research Article
Information
Parasitology , Volume 127 , Issue 3 , September 2003 , pp. 283 - 290
Copyright
© 2003 Cambridge University Press

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References

REFERENCES

ANYA, O. A. (1976). Physiological aspects of reproduction in nematodes. Advances in Parasitology 14, 267–351.CrossRefGoogle Scholar
ASAOLU, S. O., HOLLAND, C. V. & CROMPTON, D. W. T. (1991). Community control of Ascaris lumbricoides in rural Oyo State, Nigeria: mass, targeted and selective treatment with levamisole. Parasitology 103, 291–298.CrossRefGoogle Scholar
BIDINGER, P. D., CROMPTON, D. W. T. & ARNOLD, S. (1981). Aspects of intestinal parasitism in villages from rural peninsular India. Parasitology 83, 373–380.CrossRefGoogle Scholar
COOPER, P. J., CHICO, M. E., SANDOVAL, C., ESPINEL, I., GUEVARA, A., KENNEDY, M. W., URBAN, J. F. Jr., GRIFFIN, G. E. & NUTMAN, T. B. (2000). Human infection with Ascaris lumbricoides is associated with a polarized cytokine response. Journal of Infectious Diseases 182, 1207–1213.CrossRefGoogle Scholar
CROMPTON, D. W. T. (1989). Biology of Ascaris lumbricoides. In Ascariasis and its Prevention and Control (ed. Crompton, D. W. T., Nesheim, M. C. & Pawlowski, Z. S.), pp. 9–44. Taylor & Francis, London and Philadelphia.
CROMPTON, D. W. T. (1994). Ascaris lumbricoides. In Parasitic and Infectious Diseases ( ed. Scott, M. E. & Smith, G.), pp. 175–196. Academic Press Inc., London and New York.
CROMPTON, D. W. T. (2001). Ascaris and ascariasis. Advances in Parasitology 48, 285–375.CrossRefGoogle Scholar
ELKINS, D. B. & HASWELL-ELKINS, M. (1989). The weight/length profiles of Ascaris lumbricoides within a human community before mass treatment and following reinfection. Parasitology 99, 293–299.CrossRefGoogle Scholar
FALLAH, M., MIRARAB, A., JAMALIAN, F. & GHADERI, A. (2002). Evaluation of two years of mass chemotherapy against ascariasis in Hamadan, Islamic Republic of Iran. Bulletin of the World Health Organization 80, 399–402.Google Scholar
FERREIRA, C. S., FERREIRA, M. U. & NOGUEIRA, M. R. (1994). The prevalence of infection by intestinal parasites in an urban slum in Sao Paulo, Brazil. Journal of Tropical Medicine and Hygiene 97, 121–127.Google Scholar
FLORES, A., ESTEBAN, J. G., ANGLES, R. & MAS-COMA, S. (2001). Soil-transmitted helminth infections at very high altitude in Bolivia. Transactions of the Royal Society of Tropical Medicine and Hygiene 95, 272–277.CrossRefGoogle Scholar
FORRESTER, J. E. & SCOTT, M. E. (1990). Measurement of Ascaris lumbricoides infection intensity and the dynamics of expulsion following treatment with mebendazole. Parasitology 100, 303–308.CrossRefGoogle Scholar
GEENEN, P. L., BRESCIANI, J., BOES, J., PEDERSEN, A., ERIKSEN, L., FAGERHOLM, H.-P. & NANSEN, P. (1999). The morphogenesis of Ascaris suum to the infective third-stage larvae within the egg. Journal of Parasitology 85, 616–622.CrossRefGoogle Scholar
HALL, A., ANWAR, K. S. & TOMKINS, A. M. (1992). Intensity of reinfection with Ascaris lumbricoides and its implications for parasite control. The Lancet 339, 1253–1257.CrossRefGoogle Scholar
HALL, A. & HOLLAND, C. (2000). Geographical variation in Ascaris lumbricoides fecundity and its implications for helminth control. Parasitology Today 16, 540–544.CrossRefGoogle Scholar
HOLLAND, C. V., ASAOLU, S. O., CROMPTON, D. W. T., WHITEHEAD, R. R. & COOMBS, I. (1996). Targeted anhelminthic treatment of school children: effect of frequency of application on the intensity of Ascaris lumbricoides infection in children from rural Nigerian villages. Parasitology 113, 87–95.CrossRefGoogle Scholar
HOLLAND, C. V., CROMPTON, D. W., TAREN, D. L., NESHEIM, M. C., SANJUR, D., BARBEAU, I. & TUCKER, K. (1987). Ascaris lumbricoides infection in pre-school children from Chiriqui Province, Panama. Parasitology 95, 615–622.CrossRefGoogle Scholar
JANSSENS, P. G. (1985). Chemotherapy of gastrointestinal nematodiasis in man. In Chemotherapy of Gastrointestinal Helminths. Handbook of Experimental Pharmacology, vol. 77 ( ed. Vanden Bossche, H., Theinpont, D. & Janssens, P. G.), pp. 183–406. Springer Verlag, Berlin.CrossRef
JONES, H. L. (1977). Haemagglutination tests in the study of Ascaris epidemiology. Annals of Tropical Medicine and Parasitology 71, 219–226.CrossRefGoogle Scholar
JUNGERSEN, G., ERIKSEN, L., NANSEN, P. & FAGERHOLM, H.-P. (1997). Sex-manipulated Ascaris suum infections in pigs: implication for reproduction. Parasitology 115, 439–442.CrossRefGoogle Scholar
KROEGER, A., SCHULZ, B., WITTE, B., SKEWES-RAMM, R. & ETZLER, A. (1992). Helminthiases and cultural change in the Peruvian rainforest. Journal of Tropical Medicine and Hygiene 95, 104–113.Google Scholar
MAKIYA, K., TSUKAMOTO, M., UNOKI, H., SUJITA, K., MORI, N., MIKI, T. & YOKOYAMA, M. (1988). Three recent cases of ascariasis in northern Kyushu. Sangyo Ika Daigaku Zasshi 10, 123–132. (In Japanese.)CrossRefGoogle Scholar
MONZON, R. B. (1991). Replacement patterns of Ascaris lumbricoides populations in Filipino children. Southeast Asian Journal of Tropical Medicine and Public Health 22, 605–610.Google Scholar
O'LORCAIN, P. & HOLLAND, C. V. (2000). The public health importance of Ascaris lumbricoides. Parasitology 121 (Suppl.), S51–S71.CrossRefGoogle Scholar
PALMER, D. R., HALL, A., HAQUE, R. & ANWAR, K. S. (1995). Antibody isotype responses to antigens of Ascaris lumbricoides in a case-control study of persistently heavily infected Bangladeshi children. Parasitology 111, 385–393.CrossRefGoogle Scholar
PENG, W. & ZHOU, X. (2001). Experimental epidemiological study on possible influence of pig-derived Ascaris on the transmission of human ascariasis. Chinese Journal of Epidemiology 22, 116–118. (In Chinese, with English abstract.)Google Scholar
PENG, W., ZHOU, X. & CROMPTON, D. W. T. (1998). Ascariasis in China. Advances in Parasitology 41, 109–148.Google Scholar
PENG, W., CUI, X. & ZHOU, X. (2002). Comparison of the structures of natural and re-established populations of Ascaris in humans in a rural community of Jiangxi, China. Parasitology 124, 641–647.CrossRefGoogle Scholar
PENG, W., ZHOU, X., CUI, X., CROMPTON, D. W. T., WHITEHEAD, R. R., XIONG, J., WU, H., PENG, J., YANG, Y., WU, W., XU, K. & YAN, Y. (1996). Ascaris, people and pigs in rural community of Jiangxi Province, China. Parasitology 113, 545–557.Google Scholar
PENG, W., ZHOU, X., CUI, X., CROMPTON, D. W. T., WHITEHEAD, R. R., XIONG, J., WU, H., YANG, Y., WU, W., XU, K. & YAN, Y. (1998). Transmission and natural regulation of infection with Ascaris lumbricoides in a rural community in China. Journal of Parasitology 84, 252–258.CrossRefGoogle Scholar
SEO, B. S. (1990). Epidemiology and control of ascariasis in Korea. Korean Journal of Parasitology 28 (Suppl.), S49–S61.CrossRefGoogle Scholar
SEO, B. S., CHO, S. Y. & CHAI, J. Y. (1979). Frequency distribution of Ascaris lumbricoides in rural Koreans with special reference to the effect of changing endemicity. Korean Journal of Parasitology 17, 105–113.CrossRefGoogle Scholar
THEIN HLAING, THAN SAW & MYINT LWIN (1987). Reinfection of people with Ascaris lumbricoides following single 6-month and 12-month interval mass chemotherapy in Okpo village, rural Burma. Transactions of the Royal Society of Tropical Medicine and Hygiene 81, 140–146.CrossRefGoogle Scholar
WHARTON, D. A. (1980). Nematode egg-shells. Parasitology 84, 177–194.CrossRefGoogle Scholar
WONG, M. S., BUNDY, D. A. P. & GOLDEN, M. H. N. (1991). The rate of ingestion of Ascaris lumbricoides and Trichuris trichiura eggs in soil and its relationship to infection in two children's homes in Jamaica. Transactions of the Royal Society of Tropical Medicine and Hygiene 85, 89–91.CrossRefGoogle Scholar
WORLD HEALTH ORGANIZATION (1967). Control of Ascariasis. Report of a World Health Organization Expert Committee. WHO Technical Report Series No. 379. WHO, Geneva.
WORLD HEALTH ORGANIZATION (1987). Prevention and Control of Intestinal Parasitic Infections. WHO Technical Report Series No. 749. WHO, Geneva.
WORLD HEALTH ORGANIZATION (1991). Basic Laboratory Methods in Medical Parasitology. WHO, Geneva.
WORLD HEALTH ORGANIZATION (1996). Report of the WHO Informal Consultation on the use of Chemotherapy for the Control of Morbidity due to Soil-Transmitted Nematodes in Humans. WHO/CTD/sip/96. 2: Geneva.