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Current status of vaccination against African trypanosomiasis

Published online by Cambridge University Press:  05 May 2010

STEFAN MAGEZ ,
GUY CALJON ,
THAO TRAN ,
BENOÎT STIJLEMANS  and
MAGDALENA RADWANSKA
STEFAN MAGEZ*
Affiliation:
Unit of Cellular and Molecular Immunology, Vrije Universiteit Brussel (VUB), Pleinlaan 2, B-1050Brussels, Belgium Department of Molecular and Cellular Interactions, VIB, Rijvisschestraat 120, B-9052Ghent, Belgium
GUY CALJON
Affiliation:
Unit of Cellular and Molecular Immunology, Vrije Universiteit Brussel (VUB), Pleinlaan 2, B-1050Brussels, Belgium Department of Molecular and Cellular Interactions, VIB, Rijvisschestraat 120, B-9052Ghent, Belgium Unit of Entomology, Institute of Tropical Medicine Antwerp (ITM), Nationalestraat 155, B-2000Antwerp, Belgium
THAO TRAN
Affiliation:
Unit of Cellular and Molecular Immunology, Vrije Universiteit Brussel (VUB), Pleinlaan 2, B-1050Brussels, Belgium Department of Molecular and Cellular Interactions, VIB, Rijvisschestraat 120, B-9052Ghent, Belgium
BENOÎT STIJLEMANS
Affiliation:
Unit of Cellular and Molecular Immunology, Vrije Universiteit Brussel (VUB), Pleinlaan 2, B-1050Brussels, Belgium Department of Molecular and Cellular Interactions, VIB, Rijvisschestraat 120, B-9052Ghent, Belgium
MAGDALENA RADWANSKA
Affiliation:
COST Office, Avenue Louise 149, B-1050Brussels, Belgium
*
*Corresponding author: E-mail: stemagez@vub.ac.be
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Summary

Anti-trypanosomiasis vaccination still remains the best theoretical option in the fight against a disease that is continuously hovering between its wildlife reservoir and its reservoir in man and livestock. While antigentic variation of the parasite surface coat has been considered the major obstacle in the development of a functional vaccine, recent research into the biology of B cells has indicated that the problems might go further than that. This paper reviews past and current attempts to design both anti-trypanosome vaccines, as well as vaccines directed towards the inhibition of infection-associated pathology.

Keywords

TrypanosomiasisvaccinationB cells
Type
Research Article
Information
Parasitology , Volume 137 , Special Issue 14: African trypanosomiasis: New insights for disease control , December 2010 , pp. 2017 - 2027
Copyright
Copyright © Cambridge University Press 2010

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References

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