Hostname: page-component-848d4c4894-mwx4w Total loading time: 0 Render date: 2024-06-29T01:42:04.029Z Has data issue: false hasContentIssue false
  • English
  • Français

Experimental studies on the chemosterilization of Schistosoma mansoni

Published online by Cambridge University Press:  06 April 2009

Pamela Davies  and
Harold Jackson
Pamela Davies
Affiliation:
Unit of Reproductive Pharmacology, University of Manchester
Harold Jackson
Affiliation:
Unit of Reproductive Pharmacology, University of Manchester
Get access Rights & Permissions [Opens in a new window]

Extract

Treatment of mice infected with S. mansoni by various sterilants effective against male rodents produced phases of inhibition of schistosome oviposition assessed by miracidial counts. In the treated worms, besides apparent disappearance of the testes, marked involution of ovarian tissue occurred. The gonads of both male and female worms seem to be directly affected by the antifertility substances. It is suggested that gamete production in both sexes follows similar lines in contrast to the finite reservoir of meiotic oocytes in mammals.

Type
Research Article
Information
Parasitology , Volume 61 , Issue 2 , October 1970 , pp. 167 - 176
Copyright
Copyright © Cambridge University Press 1970

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Armstrong, J. C. (1965). Mating behaviour and development of Schistosomes in the mouse. Journal of Parasitology 51, 605–16.CrossRefGoogle ScholarPubMed
Coppola, J. A. (1969). An extragonadal male antifertility agent. Life Sciences 8, 43–8.CrossRefGoogle ScholarPubMed
Ericsson, R. J. & Bakeb, V. F. (1970). Male antifertility chemicals: Biological properties of U-5897 and U-15, 646. Journal of Reproduction and Fertility 21, 267–73.CrossRefGoogle Scholar
Granger, C. D. (1967). A preliminary communication describing a selective cytotoxic alkylating agent related to vitamin K. International Congress of Chemotherapy, Vienna, Austria, p. 403.Google Scholar
Hemsworth, B. N. & Jackson, H. (1965). Embryopathies induced by cytotoxic agents. In Biological Council Symposium on Embryopathic Activities of Drugs,116–37, (eds.) Robson, J. M., Sullivan, F. and Smith, R. L.. London:J. and A. Churchill Ltd.Google Scholar
Jackson, H. (1964) Effects of alkylating agents on fertility. British Medical Bulletin 20, 107–14.CrossRefGoogle ScholarPubMed
Jackson, H. (1965). Problems in the chemical control of fertility. In Biological Council Symposium on Agents Affecting Fertility,62–77, (eds.) Austin, C. R. and Perry, J. S.. London:J. and A. Churchill Ltd.Google Scholar
Jackson, H. (1966). Antifertility compounds in the male and female. American Lectures in Living Chemistry. Springfield, Illinois: C. C. Thomas.Google Scholar
Jackson, H. & Craig, A. W. (1969). Effects of alkylating chemicals on reproductive cells. Annals of the New York Academy of Sciences 160, 215–27.Google Scholar
Jackson, H., Davies, P. & Bock, M. (1968). Chemosterilization of Schistosoma mansoni. Nature (London), 218, 977.Google Scholar
Jackson, H., Jones, A. R. & Coopeb, E. R. A. (1969). Effects of hexamethylphosphoramide on rat spermatogenesis and fertility. Journal of Reproduction and Fertility 20, 263–9.Google Scholar
James, R. M. V. (1966). Haematological studies with methylene dimethanesulphate (Dimethanesulphonoxymethane). British Journal of Haematology 12, 546–54.Google Scholar
Lambert, C. R. (1964). Chemotherapy of experimental Schistosoma mansoni infections with a nitrothiazole derivative, CIBA 32,644-Ba. Annals of Tropical Medicine and Parasitology 58, 292–303.Google Scholar
Lee, H. G. & Michaels, R. M. (1968). In vitro and in vivo effects of selected metabolic inhibitors and chemotherapeutic agents on adults and egg development of Schistosoma mansoni. Experimental Parasitology 22, 256–63.Google Scholar
Standen, O. D. (1949). Experimental Schistosomiasis. II. Maintenance of Schistosoma mansoni in the laboratory, with some notes on experimental infections with S. haematobium. Annals of Tropical Medicine and Parasitology 43, 268–83.Google Scholar
Standen, O. D. (1967). Laboratory evaluation of Schistosomicidal substances. Transactions of the Royal Society of Tropical Medicine and Hygiene 61, 563–9.Google Scholar
Striebel, H. P. & Kradolfeb, F. (1966). Mode of action of CIBA 32,644-Ba in Experimental Schistosomiasis. Acta Tropica Supplement 9, 54–8.Google Scholar