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Interactions between immunity and metabolism – contributions from the metabolic profiling of parasite-rodent models

Published online by Cambridge University Press:  05 July 2010

J. SARIC
J. SARIC*
Affiliation:
Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, SW7 2AZ, London, UK
*
*Corresponding author. Dr. Jasmina Saric, Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, SW7 2AZ, London, UK, Tel.: +44 20 7594-3899; Fax: +44 20 7595-3220; E-mail: jasmina.saric@imperial.ac.uk
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Summary

A combined interdisciplinary research strategy is even more crucial in immunology than in many other biological sciences in order to comprehend the closely linked interactions between cell proliferation, molecular signalling and gene rearrangements. Because of the multi-dimensional nature of the immune system, an abundance of different experimental approaches has developed, with a main focus on cellular and molecular mechanisms. The role of metabolism in immunity has been underexplored so far, and yet researchers have made important contributions in describing associations of immune processes and metabolic pathways, such as the central role of the l-arginine pathway in macrophage activation or the immune regulatory functions of the nucleotides. Furthermore, metabolite supplement studies, including nutritional administration and labelled substrates, have opened up new means of manipulating immune mechanisms. Metabolic profiling has introduced a reproducible platform for systemic assessment of changes at the small-molecule level within a host organism, and specific metabolic fingerprints of several parasitic infections have been characterized by 1H NMR spectroscopy. The application of multivariate statistical methods to spectral data has facilitated recovery of biomarkers, such as increased acute phase protein signals, and enabled direct correlation to the relative cytokine levels, which encourages further application of metabolic profiling to explore immune regulatory systems.

Keywords

Parasite-host systemmetabolic profilingimmune systemacute phase proteinl-arginineeicosanoidsnitric oxidenucleotides
Type
Research Article
Information
Parasitology , Volume 137 , Special Issue 9: Insights into the metabolomes of parasites , August 2010 , pp. 1451 - 1466
Copyright
Copyright © Cambridge University Press 2010

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