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Introduction to immune cell signalling

Published online by Cambridge University Press:  11 November 2005

H. S. GOODRIDGE  and
M. M. HARNETT
H. S. GOODRIDGE
Affiliation:
Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow, G11 6NT, UK
M. M. HARNETT
Affiliation:
Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow, G11 6NT, UK
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Abstract

The dynamic interaction of cells of the immune system with other cells, antigens and secreted factors determines the nature of an immune response. The response of individual cells is governed by the sequence of intracellular signalling events triggered following the association of cell surface molecules during cell-cell contact or the detection of soluble molecules of host or pathogen origin. In this review we will first outline the general principles of intracellular signal transduction. We will then describe the signalling pathways triggered following the recognition of antigen, as well as the detection of cytokines, and discuss how the signalling pathways activated regulate the effector response.

Keywords

signal transductionBCR signallingcytokine receptor signallingTLR signalling
Type
Research Article
Information
Parasitology , Volume 130 , Issue S1 , March 2005 , pp. S3 - S9
Copyright
© 2005 Cambridge University Press

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