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Minocycline in the chemotherapy of murine toxoplasmosis

Published online by Cambridge University Press:  06 April 2009

K. F. Tabbara ,
S. Sakuragi  and
G. R. O'connor
K. F. Tabbara
Affiliation:
Department of Ophthalmology and the Francis I. Proctor Foundation for Research in Ophthalmology, University of California, San Francisco, California
S. Sakuragi
Affiliation:
Department of Ophthalmology and the Francis I. Proctor Foundation for Research in Ophthalmology, University of California, San Francisco, California
G. R. O'connor
Affiliation:
Department of Ophthalmology and the Francis I. Proctor Foundation for Research in Ophthalmology, University of California, San Francisco, California
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Summary

The effects of minocycline alone or in combination with sulphadiazine were evaluated against acute murine toxoplasmosis and compared with the efficacy of pyrimethamine and sulphadiazine. The data presented show that mice could be protected from acute toxoplasmosis by minocycline, in spite of using a virulent strain of Toxoplasma gondii, a large inoculum, and a delay in the administration of the drug. Acute toxoplasmic infection in mice could be eradicated by a minocycline–sulphadiazine combination, which was found to be as effective as pyrimethamine–sulphadiazine combination therapy.

Type
Research Article
Information
Parasitology , Volume 84 , Issue 2 , April 1982 , pp. 297 - 302
Copyright
Copyright © Cambridge University Press 1982

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