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Biotechnological utilization of plant genetic resources for the production of phytopharmaceuticals

Published online by Cambridge University Press:  12 February 2007

H. Rischer  and
K.-M. Oksman-Caldentey
H. Rischer*
Affiliation:
VTT Biotechnology, FIN-02044, Espoo, Finland
K.-M. Oksman-Caldentey
Affiliation:
VTT Biotechnology, FIN-02044, Espoo, Finland
*
*Corresponding author: E-mail: heiko.rischer@vtt.fi
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Abstract

Natural products from plants are still important sources for the development of drugs, despite their recent neglect in pharmaceutical discovery programmes. The rapidly dwindling number of species endangers the availability of these natural compounds, which are characterized by the immense chemical and functional diversity ultimately responsible for their pharmaceutical activity. Although many steps in the drug discovery process have been continuously modified during recent years, a common dilemma is still unresolved, i.e. the supply crisis for hits discovered in rare wild plants due to their inaccessibility or lack of reproducibility. New technology, combining tissue culture, functional genomics and metabolomics, shows promise to overcome these problems and even to supply a greater chemical diversity of compounds.

Keywords

cell culturescombinatorial biochemistryfunctional genomicsmetabolomicsplant-derived pharmaceuticals
Type
Research Article
Information
Plant Genetic Resources , Volume 3 , Issue 2 , August 2005 , pp. 83 - 89
Copyright
Copyright © NIAB 2005

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