Hostname: page-component-84b7d79bbc-g5fl4 Total loading time: 0 Render date: 2024-07-28T23:25:18.770Z Has data issue: false hasContentIssue false

Diazepam and Alcohol Potentiation in Passengers

Published online by Cambridge University Press:  17 February 2017

Vicente Danuzio Monterrosso
Affiliation:
Medical Division of the Rio de Janeiro International Airport, Rio de Janeiro, Brazil

Extract

There is no record in the history of medicine of a group of drugs which has gained such a reputation as the benzodiazepines, mainly among psychiatrists and physicians, who augmented their therapeutic arsenal with these drugs which have a safe and effective action. The benzodiazepines have many indications, with special emphasis in the treatment of anxiety, sleep disturbances, muscular spasms, convulsions, etc. There is, however, a difference between therapeutic and abusive usage and there is a danger of exposing an important drug to the risk of being transformed into a psychological crutch.

Airports are complex cosmopolitan units which receive millions of human beings, many of them suffering from tension which they try to hide. Many an air passenger takes, as a precaution, about 10 mg of diazepam (ValiumR). Depending upon the weather conditions and check-in problems, they may take another pill before boarding the plane. After take-off, either because they have forgotten the warning or because they choose to ignore the risks, they have a few drinks, which are served by the airline personnel to help ease tensions and sedate the group. A few moments later, the crew have one or more serious problems. Initially, the passenger becomes excited and aggressive. After being controlled, he reveals a concomitant anxiety. At the end of his trip, he is taken to the airport doctor. Following the routine examination, and familiar with the situation, the doctor knows that his patient is suffering from potentiation of alcohol by diazepam.

Type
Section Three—Definitive Medical Care
Copyright
Copyright © World Association for Disaster and Emergency Medicine 1985

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1 Goldberg, L. Alcohol, CNS-active drugs and driving skill. International Congress of Int. Fed. Hygiene and Preventive Med., Vienna, May 24-26, 1965.Google Scholar
2 Myrsten, AL, Goldberg, L, Neri, A. Interaction between alcohol and tranquilizing drugs. Psychological Laboratories, Univ. Stockholm 1971; No. 321.Google Scholar
3 Landaver, A, Lacock, A, Prott Springer, FW. The effect of Medazepan and Alcohol on Cognitive and Motor Skills Use. Car Driving, Berlin: Springer-Verlag, 1974.Google Scholar
4 Bernheim, J, Schwarz W, Michiels. Effects psycho-physiques du diazepam et d'une faible dose d'alcool chez l'homme. Med Wschr 1973; 103:863870.Google Scholar
5 Hoffner, E. Lack of potentiation by chlordizepoxide (librium) of depression or excitation due to alcohol. J Can Med Assoc 1962; 87:920.Google Scholar
6 Isaac, M et al. Studies of combination of ethanol with methohexitone and diazepam. Brit J Anaesth 1970; 42:521.CrossRefGoogle ScholarPubMed
7 Morland, J, et al. Combined effect of diazepam and ethanol on mental and psychomotor function. Acta Pharmacol Toxicol 1974; 34:5.CrossRefGoogle Scholar
8 Dundee, JW, et al. Alcohol and the benzodiazepines. Quart J Stud Alc 1971; 32:960.Google Scholar
9 Goldberg, L. Behavioral and physiological effects of alcohol on man. Psychosom Med 1966; 28:570.Google Scholar
10 Linnoila, M, Mattila, MJ. Drug interaction on psychomotor skills related to driving: Diazepam and alcohol. Eur J Clin Pharmacol 1973; 5:186.Google Scholar
11 Dundee, WJ, Haslett, WKH. The benzodiazepines. Brit J Anaesth 1970; 42:217.Google Scholar
12 Reggiani, G, Hurliman, A. Some aspects of the experimental and clinical toxicology of chlordiazepoxide. Proc. E.S.S.D.T., 9, Toxicity and Side Effects of Psychotropic Drugs. Paris, Feb. 1967.Google Scholar
13 Valentim, F. Efeitos psicofisiologicos dos benzodiazepinicos. Simposio Internacional Benzodiazepines, Rio de Janeiro, Brazil, 1979.Google Scholar
14 Kaim, C. Tratamento do alcoolismo. Experiencia com benzodiazepinicos. Institute de Pesquisas Biometricas, Washington, DC, USA.Google Scholar
15Bueno J. Emprego clinico por tempo prolongado de ansioliticos. Docente Libre de Faculdade de Medicina da UFRJ.Google Scholar
16 Huefely, WE. Base biologica dos efeitos terapeuticos das benzodiazepinas. Dept de Pesquisa Farmaceutica. F. Hoffmann, La Roche, Basel, Switzerland.Google Scholar
17 Kaplan, A, Crouthanel, WG. Farmacocinetica das benzodiazepinas. Hoffmann La Roche, Nutley, N.J., USA.Google Scholar