Hostname: page-component-5c6d5d7d68-qks25 Total loading time: 0 Render date: 2024-08-24T07:23:38.629Z Has data issue: false hasContentIssue false
  • English
  • Français

Dose-response effects of exogenous letrozole on Day 11.5 porcine uterine and conceptus oestradiol concentrations

Published online by Cambridge University Press:  23 November 2017

CJ Ashworth ,
L Beattie ,
P Summers ,
F R Dunshea ,
L Nugent ,
K L Fry  and
R C Fry
CJ Ashworth*
Affiliation:
SAC, Bucksburn, Aberdeen, United Kingdom
L Beattie
Affiliation:
Rowett Research Institute, Bucksburn, Aberdeen, United Kingdom
P Summers
Affiliation:
James Cook University, Townsville, Queensland, Australia
F R Dunshea
Affiliation:
Victorian Institute of Animal Sciences, Werribee, Victoria, Australia
L Nugent
Affiliation:
Victorian Institute of Animal Sciences, Werribee, Victoria, Australia
K L Fry
Affiliation:
Animal Reproduction Company, Werribee, Victoria, Australia
R C Fry
Affiliation:
Animal Reproduction Company, Werribee, Victoria, Australia
*
Email: cheryl.ashworth@sac.ac.uk
Get access

Extract

Previous studies from our group suggest that the synchronised onset of oestradiol secretion by preimplantation conceptuses from Meishan pigs may contribute to the enhanced prenatal survival characteristic of this breed (Ashworth and Pickard, 1998). We have recently reported that in vitro, the onset of oestradiol secretion by conceptuses can be regulated in a dose-dependent manner by an aromatase inhibitor (letrozole; Ashworth et al., 2005). Before commencing in vivo trials to assess the efficacy of letrozole to promote prenatal survival, it is important to determine whether exogenous letrozole reaches the uterine lumen and to establish the relationship between the dose administered and the impact on oestradiol secretion at the conceptus-uterine interface.

Type
Poster presentations
Information
Proceedings of the British Society of Animal Science , Volume 2006 , March 2006 , pp. 152
Copyright
Copyright © 2016 The American Society of International Law

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Ashworth, C.J. and Pickard, A.R. (1998) Embryo Survival and Prolificacy. In ‘Progress in Pig Science’ Eds Wiseman, J., Varley, M.A. and Chadwick, J.. Nottingham University Press, Nottingham. pp 303-325.Google Scholar
Ashworth, C.J., Summers, P., Nugent, L., Dunshea, F.D., Fry, K and Fry, R (2005) Effect of letrozole on in vitro oestradiol secretion by the porcine conceptus. Proc. 7th Int Cong Pig Repro. Rolduc, The Netherlands, p86.Google Scholar