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Effect of dietary polyunsaturated fatty acids on uterine endometrial gene expression of enzymes involved in prostaglandin biosynthesis in cattle

Published online by Cambridge University Press:  23 November 2017

S.M. Waters ,
S. Childs ,
J.M. Sreenan ,
A. Hennessy ,
C. Stanton  and
D.A. Kenny
S.M. Waters*
Affiliation:
Teagasc, Animal Production Research Centre, Mellows Campus, Athenry, Co. Galway, Ireland
S. Childs
Affiliation:
Teagasc, Animal Production Research Centre, Mellows Campus, Athenry, Co. Galway, Ireland
J.M. Sreenan
Affiliation:
Teagasc, Animal Production Research Centre, Mellows Campus, Athenry, Co. Galway, Ireland
A. Hennessy
Affiliation:
Teagasc, Dairy Products Research Centre, Moorepark, Fermoy, Co. Cork, Ireland
C. Stanton
Affiliation:
Teagasc, Dairy Products Research Centre, Moorepark, Fermoy, Co. Cork, Ireland
D.A. Kenny
Affiliation:
School of Agriculture, Food Science and Veterinary Medicine, University College Dublin, Belfield, Dublin 4, Ireland
*
Email:Sinead.Waters@teagasc.ie
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Extract

The modern high-producing dairy cow is sub-fertile. Early embryo loss, within the first 16 days of gestation, is the greatest contributor to reproductive wastage (Sreenan et al., 2001), though the causes for this are not well understood. Nutrition plays a fundamental role in reproduction and specifically there is emerging evidence that supplemental polyunsaturated dietary fatty acids (PUFA) can increase cow fertility (Thatcher et al., 2006). For example, in-vitro studies suggest that the ω-3 PUFAs, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) may be pivotal in the suppression of endometrial prostaglandin F2α synthesis, a critical regulator of luteolysis and hence embryo survival, though the biochemical pathways involved have not been elucidated. The objective of this study was to determine the effect of dietary supplementation of ω-3 PUFA on mRNA expression of key uterine endometrial genes involved in PGF2α biosynthesis.

Type
Theatre Presentations
Information
Proceedings of the British Society of Animal Science , Volume 2007 , April 2007 , pp. 59
Copyright
Copyright © The British Society of Animal Science 2007

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References

MacLaren, L.A., Guzeloglu, A, Michel, F. and Thatcher, W.W. 2006. Peroxisome proliferator-activated receptor (PPAR) expression in cultured bovine endometrial cells and response to omega-3 fatty acid, growth hormone and agonist stimulation in relation to series 2 prostaglandin production. Domestic Animal Endocrinology. 30:155–169.CrossRefGoogle ScholarPubMed
Sreenan, J.M., Diskin, M.G. and Morris, D.G. 2001. Embryo survival in cattle: a major limitation to the achievement of high fertility. Fertility in the High-Producing Dairy Cow (BSAS OP No 26) 2007:93–10.Google Scholar
Thatcher, W.W., Bilby, T.R., Bartolome, J.A., Silvestre, F., Staples, C.R. and Santos, J.E.P. 2006. Strategies for improving fertility in the modern dairy cow. Theriogenology. 65: 30–44.CrossRefGoogle ScholarPubMed