There is a risk of chronic copper poisoning (CCP) in breeds such as the Texel whenever they are liberally fed pelleted commercial rations. Addition of the Cu- antagonists iron (Fe), zinc (Zn) or a combination of molybdenum and sulphur (Mo + S) to the diet have each significantly reduced liver Cu and risk of CCP in separate experiments but usually in less susceptible breeds. ‘Cocktails’ of antagonists are routinely added to compound feeds to reduce the risk of CCP but components and inclusion rates vary and the additivity of their protective effects has not been studied. Furthermore, the apparent inability of Texels to limit hepatic Cu retention (HCR) has called into question the reliability of antagonist cocktails for this breed (Suttle et al 2002). The objective of this experiment was to test the ability of a cocktail of Mo, S and Zn to restrict HCR by Texel rams, given a pelleted commercial concentrate that raised Cu in the total ration to the EC maximum permitted level of 17mg/kgDM.