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Leucine metabolism across the gastrointestinal tract of sheep infected with Trichostrongylus colubriformis

Published online by Cambridge University Press:  05 November 2021

Feng Yu ,
L.A. Bruce ,
R.L. Coop  and
J.C. MacRae
Feng Yu
Affiliation:
Rowett Research Institute, Bucksbum, Aberdeen, AB21 9SB, U.K.
L.A. Bruce
Affiliation:
Rowett Research Institute, Bucksbum, Aberdeen, AB21 9SB, U.K.
R.L. Coop
Affiliation:
Moredun Research Institute, 408 Gilmerton Road, Edinburgh, EH17 7JH, U.K.
J.C. MacRae
Affiliation:
Rowett Research Institute, Bucksbum, Aberdeen, AB21 9SB, U.K.
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Extract

In previous studies where sheep were subjected to experimental subclinical Trichostrongylus colubriformis infections, protein metabolism was seriously impaired during both the initial infection (5-7 weeks at early dosing) and the subsequent immune response (11-13 weeks of dosing) periods (see MacRae, 1993). Symonds and Jones (1983) reported that T. colubriformis infection increased the rates of protein synthesis in the small and large intestines of guinea pigs by 24 and 70% respectively, however there are no equivalent data in farm animals. In the present study trans-organ catheterisation procedures have been coupled with mass isotope tracer kinetics to examine leucine metabolism across the gastrointestinal (g.i.) tract of lambs subjected to subclinical T. colubriformis infection.

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Information
Proceedings of the British Society of Animal Science , Volume 1998 , 1998 , pp. 1
Copyright
Copyright © The British Society of Animal Science 1998

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References

MacRae, J.C. 1993. Metabolic consequences of intestinal parasitism. Proceedings of the Nutrition Society 52: 121–130.CrossRefGoogle ScholarPubMed
MacRae, J.C., Bruce, L.A., Brown, D.S., Farningham, D.A.H. & Franklin, M. 1997. Absorption of amino acids from the intestine and their net flux across the mesenteric- & portal-drained viscera of lambs. Journal of Animal Science(in press).10.2527/1997.75123307xCrossRefGoogle Scholar
Symonds, L.E.A. & Jones, W.O. 1983. Intestinal protein synthesis in guinea pigs infected with Trichostrongylus colubriformis . InternationalJoumalforParasitology 13: 309–312.Google Scholar