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Study of the bone morphogenetic protein 15 (BMp15) mutation in Moghani sheep using RFLP method

Published online by Cambridge University Press:  22 November 2017

Z Nemati  and
A Barzegari
Z Nemati*
Affiliation:
Department of Animal Science, Faculty of Agriculture, University of Tabriz, Tabriz, Islamic Republic of Iran Young Researchers Club, Tabriz, Islamic Republic of Iran
A Barzegari
Affiliation:
Biotechnology Research Institute for Northwest & West of Iran, Tabriz, Islamic Republic of Iran
*
Email: znnemati@yahoo.com
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Extract

The Moghani is the main fat-tailed type of sheep in north-west of Iran and north-east of Turkey, where it is raised for meat, milk and carpet wool. In sheep, a wide range in litter size has been observed among different breeds and within breeds. Several genes have been recently identified that affect female fecundity in domesticated sheep such as BMP15 gene which encodes bone morphogenic protein 15 (Davis 2005 and Hanrahan et al,. 2004) and is a member of the transforming growth factor b (TGFb) super family (Galloway et al, 2000). The identification of the BMP15 mutation is important for the sheep industry and those involved in the study of mammalian fertility. In this study we investigated mutation of BMP15 gene in Moghani sheep in Iran.

Type
Theatre Presentations
Information
Proceedings of the British Society of Animal Science , Volume 2009 , April 2009 , pp. 181
Copyright
Copyright © The British Society of Animal Science 2009

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References

Davis, GH. 2005. Major genes affecting ovulation rate in sheep. Genet Sel. Evol. 37, S11–S23.CrossRefGoogle ScholarPubMed
Hanrahan, JP, Gregan, SM, Mulsant, P, Mullen, M, Davis, GH, et al. 2004. Mutations in the genes for oocyte-derived growth factors GDF9 and BMP15 are associated with both increased ovulation rate and sterility in Cambridge and Belclare sheep (Ovis aries). Biol Reprod 70, 900–909.Google Scholar
Galloway, SM, McNatty, KP, Cambridge, LM, Laitinen, MPE, Juengel, JL, et al. 2000 Mutations in an oocyte-derived growth factor gene (BMP15) cause increased ovulation rate and infertility in a dosage-sensitive manner. Nat Genet 25, 279–283.Google Scholar