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Intrafetal infusion of leptin suppresses expression of leptin mRNA and increases the proportion of multilocular adipose tissue in fetal perirenal fat in the sheep

Published online by Cambridge University Press:  20 November 2017

BS Yuen ,
PC Owens ,
BS Muhlhausler ,
CT Roberts ,
ME Symonds ,
DH Keisler ,
JH McFarlane  and
IC McMillen
BS Yuen
Affiliation:
Department of Physiology, Adelaide University, SA 5005, Australia
PC Owens
Affiliation:
Department of Obstetrics and Gynaecology, Adelaide University, SA 5005, Australia
BS Muhlhausler
Affiliation:
Department of Physiology, Adelaide University, SA 5005, Australia
CT Roberts
Affiliation:
Department of Obstetrics and Gynaecology, Adelaide University, SA 5005, Australia
ME Symonds
Affiliation:
Division of Child Health, Queens Medical Centre, Nottingham, UK
DH Keisler
Affiliation:
Department of Animal Science, University of Missouri, Columbia, MO, US
JH McFarlane
Affiliation:
Department Animal Science, University of New England, Armidale NSW, Australia
IC McMillen
Affiliation:
Department of Physiology, Adelaide University, SA 5005, Australia
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Extract

Leptin, a 16kDa polypeptide hormone, is synthesised and secreted by adipocytes and acts to regulate energy stores and energy expenditure in the adult. In the newborn infant, there is a positive correlation between cord blood leptin concentrations and neonatal fat mass but it is unknown whether leptin can act to regulate the endocrine or metabolic characteristics of adipose tissue before birth. We have therefore tested the hypothesis that an intrafetal infusion of leptin will act to alter on leptin mRNA expression and the morphological characteristics of perirenal fat, the major fat depot in the sheep fetus during late gestation.

Type
Theatre Presentations
Information
Proceedings of the British Society of Animal Science , Volume 2002 , 2002 , pp. 6
Copyright
Copyright © The British Society of Animal Science 2002

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