We study topological properties of the correspondence of prime spectra associated with a non-commutative ring homomorphism $R\rightarrow S$. Our main result provides criteria for the adjointness of certain functors between the categories of Zariski closed subsets of $\spec R$ and $\spec S$; these functors arise naturally from restriction and extension of scalars. When $R$ and $S$ are left Noetherian, adjointness occurs only for centralizing and ‘nearly centralizing’ homomorphisms.