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Isotopes in nutrition research

Published online by Cambridge University Press:  28 February 2007

Vernon R. Young  and
Alfred Ajami
Vernon R. Young*
Affiliation:
Laboratory of Human Nutrition, School of Science and Clinical Research Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Alfred Ajami
Affiliation:
MassTrace Inc., Woburn, MA 01801, USA
*
*Corresponding author: Dr Vernon R. Young, fax +1 617 253 9658, email vryoung@mit.edu
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Abstract

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The present lecture begins with a brief overview of the professional and scientific journey taken by Rudolf Schoenheimer, before turning to a discussion of the power of isotopic tracers in nutrition research. Schoenheimer's remarkable contributions to the study of intermediary metabolism and the turnover of body constituents, based initially on compounds tagged with 2H and later with 15N, spanned a mere decade. It is difficult, however, to overestimate the enormous impact of Schoenheimer's research on the evolution of biological science. After a relative hiatus, following Schoenheimer's death in 1941, in the use of stable nuclides as tracers in metabolism and nutrition, especially in human subjects, there is now an expanded and exciting range of techniques, experimental protocols and stable-isotope tracer compounds that are helping to probe the dynamic aspects of the metabolism of the major energy-yielding substrates, amino acids and other N-containing compounds, vitamins and mineral elements in human subjects. Various aspects of the contemporary applications of these tracers in nutrition research are covered in the present lecture.

Keywords

Rudolf SchoenheimerStable-isotope tracersIsotope labelling techniquesIsotope measurement
Type
The Rudolf Schoenheimer Centenary Lecture
Information
Proceedings of the Nutrition Society , Volume 58 , Issue 1 , February 1999 , pp. 15 - 32
Copyright
Copyright © The Nutrition Society 1999

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