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The role of ubiquitin–proteasome-dependent proteolysis in the remodelling of skeletal muscle

Published online by Cambridge University Press:  05 March 2007

Daniel Taillandier ,
Lydie Combaret ,
Marie-Noëlle Pouch ,
Susan E. Samuels ,
Daniel Béchet  and
Didier Attaix
Daniel Taillandier
Affiliation:
Human Nutrition Research Centre of Clermont-Ferrand and National Institute of Agricultural Research, Nutrition and Protein Metabolism Unit, 63122 Ceyrat, France
Lydie Combaret
Affiliation:
Human Nutrition Research Centre of Clermont-Ferrand and National Institute of Agricultural Research, Nutrition and Protein Metabolism Unit, 63122 Ceyrat, France
Marie-Noëlle Pouch
Affiliation:
Human Nutrition Research Centre of Clermont-Ferrand and National Institute of Agricultural Research, Nutrition and Protein Metabolism Unit, 63122 Ceyrat, France
Susan E. Samuels
Affiliation:
Human Nutrition Research Centre of Clermont-Ferrand and National Institute of Agricultural Research, Nutrition and Protein Metabolism Unit, 63122 Ceyrat, France
Daniel Béchet
Affiliation:
Human Nutrition Research Centre of Clermont-Ferrand and National Institute of Agricultural Research, Nutrition and Protein Metabolism Unit, 63122 Ceyrat, France
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Abstract

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In skeletal muscle, as in any mammalian tissue, protein levels are dictated by relative rates of protein synthesis and breakdown. Recent studies have shown that the ubiquitin–proteasome-dependent proteolytic pathway is mainly responsible for the breakdown of myofibrillar proteins. In this pathway proteins that are to be degraded are first tagged with a polyubiquitin degradation signal. Ubiquitination is performed by the ubiquitin-activating enzyme, ubiquitin-conjugating enzymes and ubiquitin–protein ligases, which are responsible for the recognition of specific substrates. Polyubiquitinated protein substrates are then specifically recognised and degraded by the 26S proteasome. The present review focuses on: (1) the mechanisms of ubiquitination–deubiquitination that make the system highly selective; (2) the mechanisms of proteolysis in skeletal muscle. In particular, the role of the system in the remodelling of skeletal muscle during exercise and disuse and in recovery or regeneration that prevails during post-atrophic conditions is reviewed.

Keywords

Muscle activity and disuseExerciseMuscle wastingUbiquitin–proteasome-dependent proteolysis
Type
Symposium 5: Muscle hypertrophy: the signals of insulin, amino acids and exercise
Information
Proceedings of the Nutrition Society , Volume 63 , Issue 2 , May 2004 , pp. 357 - 361
Copyright
Copyright © The Nutrition Society 2004

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