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The Characterization of Anti-lymphocytic Antibodies*

Published online by Cambridge University Press:  11 June 2012

Keith James
Keith James
Affiliation:
Department of Surgical Science, University of Edinburgh
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Extract

During recent years the heterogeneity of equine antibodies to a variety of antigens has been convincingly demonstrated (Rockey, Klinman and Karush 1964; Raynaud, Iscaki and Mangalo 1965; Allen, Sirisina and Vaughan 1965; Klinman et al. 1966; Klinman and Karush 1967; Johnson and Allen 1968). For example, extensive studies on equine anti-hapten antibodies have shown that the IgG fraction of horse serum contains at least four different proteins, namely the IgGa, IgGb, IgGc and IOS IgG globulins in addition to the IgG(T) and IgM proteins (Rockey et al. 1964; Klinman et al. 1966). These antibodies differ widely in their ability to precipitate the protein-bound hapten and to fix complement, and their concentrations and binding affinities vary considerably during a course of immunization (Klinman et al. 1966).

Type
Research Article
Information
Proceedings of the Royal Society of Edinburgh, Section B: Biological Sciences , Volume 70 , Issue 4 , 1969 , pp. 329 - 340
Copyright
Copyright © Royal Society of Edinburgh 1969

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Footnotes

*

This paper was assisted in publication by a grant from the Carnegie Trust for the Universities of Scotland.

References

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