The Race A/Race B hybrid females of D. pseudo-obscura have a high percentage of fertility, comparable with that of females of pure race. The number and viability of their offspring, however, are largely affected by the genetic constitution of the hybrid female as well as by that of the male to which she is mated in the backcross. Hence the performance of any given hybrid is determined in the first instance by the actual strains of the pure races which are used in making the P1 racial cross. Generally speaking the results are of the same order whenever the same strains are used. The progenies of hybrid females of different genetic constitution may differ in three main aspects: (1) The total number of offspring may be comparable with that usually obtained in a pure race cross; it may be reduced to any extent; in certain matings it is consistently at zero. (2) The sex ratio may be completely normal or male-deficient or female-deficient in any degree; completely uni-sexual progenies are sometimes obtained. (The above observations are mainly in agreement with reports of earlier writers; cf. Lancefield, 1929, Dobzhansky, 1936, Mampell, 1941, Sturtevant, 1937.) (3) “Viability characters,” i.e. those affecting general vigour and physical normality, may be of a high or a low grade; some progenies are comparable in this respect with the pure race, the only exception being that they show a much greater range of variation in body-size of both sexes, and in the testis size of males, abnormalities which are common to all back-cross progenies whatever the genetic constitution of the mother or father. Some progenies show in addition deformities of a peculiar type usually affecting the abdomen and occasionally the legs and wings.