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XI.—Further Observations on the Liver Clearance of Bromo-sulphthalein in the Fowl and its Relation to Œstrogen-androgen Balance*

Published online by Cambridge University Press:  11 June 2012

J. G. Campbell
J. G. Campbell
Affiliation:
British Empire Cancer Campaign Unit at The Poultry Research Centre, Edinburgh
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Synopsis

Previous work has shown a sex difference dependant upon œstrogen-androgen balance, in the rate of clearance by the fowl liver of intravenously administered sodium bromosulphthalein. Further observations reported here indicate an apparent rapid fluctuation of the Œ-A balance which takes place in immature chickens, both sexes snowing what is interpreted as hyperœstrogenization about the age of twelve weeks. Attention is drawn to other evidence that profound metabolic and hormonal changes occur at this stage. The effect of exogenous sex-hormones on the clearance rate of BSP has been further studied, particularly the influence of extra androgen on adult males with aberrant clearances unassociated with liver lesions. More evidence for the relation between the rate of BSP clearance and the Œ-A balance is provided by the study of the effect of cessation of ovulation on the clearance, and the effect of the development of virilizing tumours at the site of the rudimentary right ovary after left ovariectomy. Other changes which confirm hyperœstrogenization as assessed by the BSP clearance test are (a) decrease of the packed cell volume, (b) the development of a precipitable phospholipid in the plasma, (c) renal vascular changes, (d) adrenal cortical hyperplasia, (e) a frequent association with oviduct ligament “fibroids” and persistent cystic right oviducts.

Type
Research Article
Information
Proceedings of the Royal Society of Edinburgh, Section B: Biological Sciences , Volume 67 , Issue 4 , 1960 , pp. 303 - 318
Copyright
Copyright © Royal Society of Edinburgh 1960

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Footnotes

*

This paper was assisted in publication by a grant from the Carnegie Trust for the Universities of Scotland.

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