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Selective serotonin re-uptake inhibitors: use in depression

Published online by Cambridge University Press:  02 January 2018

I. N. Ferrier ,
T. Silverstone  and
D. Eccleston
I. N. Ferrier
Affiliation:
Department of Psychiatry, School of Neuroscience, University of Newcastle upon Tyne NE1 4LP
T. Silverstone
Affiliation:
Department of Psychological Medicine, St Bartholomew's Hospital, London EC1A 7BE
D. Eccleston
Affiliation:
Department of Psychiatry, School of Neuroscience, University of Newcastle upon Tyne NE1 4LP
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This short review outlines the clinical profile of the selective serotonin re-uptake inhibitors (SSRIs). There has been much recent publicity and promotion of this group of drugs and this review attempts to give a balanced account of their current place in the treatment of depression. Although a large number of preclinical and clinical trials have been carried out many questions and problems remain – it is important to proceed carefully and carry out (and replicate) controlled independent clinical trials. The views of general psychiatrists and GPs about these drugs in normal clinical practice will be the acid test – this will be particularly important in view of their cost.

Type
Keynotes
Information
Psychiatric Bulletin , Volume 16 , Issue 12 , December 1992 , pp. 737 - 739
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
Copyright © Royal College of Psychiatrists 1992

References

Aberg-Wistedt, A. (1989) The antidepressant effects of 5-HT uptake inhibitors. British Journal of Psychiatry, 155, (Suppl 8), 32–40.Google Scholar
Danish University Antidepressant Group (1986) Citalopram: clinical effect profile in comparison with clomipramine. A controlled multicenter study. Psychopharmacology, 90, 131–138.Google Scholar
Danish University Antidepressant Group (1990) Paroxetine: a selective serotonin reuptake inhibitor showing better tolerance, but weaker antidepressant effect than clomipramine in a controlled multicenter study. Journal of Affective Disorders, 18, 289–299.Google Scholar
Doogan, D. P. & Caillard, V. (1988) Sertraline: a new antidepressant. Journal of Clinical Psychiatry, 49 (suppl), 84–87.Google Scholar
Dunbar, G. C. (1991) Paroxetine in the treatment of severe (melancholic) depression. Biological Psychiatry, 29, 255S.Google Scholar
Hirmatsu, K.-I., Takakashi, R., Mori, A. et al (1983) A multicentre double-blind comparative trial of zimelidine and imipramine in primary major depressive illness. Acta Psychiatrica Scandinavica, 68 (Suppl 308), 41–54.Google Scholar
Lipinski, J., Mallya, G., Zimmerman, P. & Pope, H. (1989) Fluoxetine-induced akathisia: clinical and theoretical implications. Journal of Clinical Psychiatry, 50, 339–342.Google ScholarPubMed
Montgomery, S. A. & Fineberg, N. (1989) Is there a relationship between serotonin receptor subtypes and selectivity of response in specific psychiatric illnesses? British Journal of Psychiatry, 155, (Suppl 8), 63–70.Google Scholar
Ottevanger, E. A. (1991) The efficacy of fluvoxamine in patients with severe depression. British Journal of Clinical Research, 2, 125–132.Google Scholar
Reimherr, F. W., Wood, D. R., Byerley, B., Brainard, J. & Grosser, B. I. (1984) Characteristics of responders to fluoxetine. Psychopharmacology Bulletin, 20, 70–72.Google Scholar
Tyrer, P., Marsden, C. A., Casey, P. et al (1987) Clinical efficacy of paroxetine in resistant depression. Journal of Psychopharmacology. 1, 251–7.Google Scholar
Wernicke, J. F. & Bremner, J. D. (1986) Fluoxetine – important in the long term treatment of depression. British Journal of Clinical Practice, 7, 17–23.Google Scholar
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