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Monitoring of tricyclic antidepressant plasma levels and clinical response: a review of the literature. Part I.

Published online by Cambridge University Press:  28 April 2020

I.R. De Oliveira ,
P.A.S. Do Prado-Lima  and
B. Samuel-Lajeunesse
I.R. De Oliveira*
Affiliation:
Clinique des Maladies Mentales et de l’Encéphale, 100, rue de la Santé, 75674Paris Cedex 14, France Departamento de Farmacologia e Fisiologia, ICS, Universidade Federal da Bahia, Vale do Canela, 40.140, Salvador, Bahia, Brazil
P.A.S. Do Prado-Lima
Affiliation:
Clinique des Maladies Mentales et de l’Encéphale, 100, rue de la Santé, 75674Paris Cedex 14, France
B. Samuel-Lajeunesse
Affiliation:
Clinique des Maladies Mentales et de l’Encéphale, 100, rue de la Santé, 75674Paris Cedex 14, France
*
Reprint requests to: I.R. de Oliveira al the above address (Brazil).
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Summary

Part I of this paper presents a comprehensive review of plasma level monitoring of tricyclic antidepressants (TCAs) and their relationship to clinical response to antidepressant therapy. Imipramine, nortriptyline, amitriptyline, clomipramine and desipramine are the most widely studied TCAs in this regard. Typical therapeutic plasma concentration ranges are suggested for some of these agents, although a consensus is lacking.

Résumé

Résumé

La première partie de cet article présente une revue exhaustive concernant le contrôle des taux plasmatiques des antidépresseurs tricycliques (ADT) et le rapport entre leurs concentrations plasmatiques et la réponse clinique. L'imipramine, la nortriplyline, l’amitriptyline, la clomipramine et la désipramine sont les ADT les plus étudiés en ce qui concerne ce sujet. De nombreux auteurs suggèrent l'existence de taux plasmatiques thérapeutiques, bien qu'un consensus n’existe pas.

Keywords

tricyclic antidepressantsplasma levelsclinical outcomeimipraminenortriptylineamitriptylineclomipraminedesipramineantidépresseurs tricycliquestaux plasmatiquesréponse cliniqueimipraminenortriptylineamitriptylineclomipraminedésipramine
Type
Review
Information
Psychiatry and Psychobiology , Volume 4 , Issue 1 , 1989 , pp. 43 - 60
Copyright
Copyright © European Psychiatric Association 1989

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