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Auditory verbal hallucinations: neuroimaging and treatment

Published online by Cambridge University Press:  07 July 2016

M. M. Bohlken ,
K. Hugdahl  and
I. E. C. Sommer
M. M. Bohlken
Affiliation:
Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands
K. Hugdahl
Affiliation:
Department of Biological and Medical Psychology, University of Bergen, Bergen, Norway Division of Psychiatry, Haukeland University Hospital, Bergen, Norway NORMENT Center of Excellence, University of Bergen, Norway
I. E. C. Sommer*
Affiliation:
Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands
*
*Address for correspondence: I. E. C. Sommer, M.D., Ph.D., Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Heidelberglaan 100, 3584CX Utrecht, The Netherlands. (Email: i.sommer@umcutrecht.nl)
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Abstract

Auditory verbal hallucinations (AVH) are a frequently occurring phenomenon in the general population and are considered a psychotic symptom when presented in the context of a psychiatric disorder. Neuroimaging literature has shown that AVH are subserved by a variety of alterations in brain structure and function, which primarily concentrate around brain regions associated with the processing of auditory verbal stimuli and with executive control functions. However, the direction of association between AVH and brain function remains equivocal in certain research areas and needs to be carefully reviewed and interpreted. When AVH have significant impact on daily functioning, several efficacious treatments can be attempted such as antipsychotic medication, brain stimulation and cognitive–behavioural therapy. Interestingly, the neural correlates of these treatments largely overlap with brain regions involved in AVH. This suggests that the efficacy of treatment corresponds to a normalization of AVH-related brain activity. In this selected review, we give a compact yet comprehensive overview of the structural and functional neuroimaging literature on AVH, with a special focus on the neural correlates of efficacious treatment.

Keywords

Auditory verbal hallucinationshallucinationsmagnetic resonance imagingtreatment
Type
Invited Review
Information
Psychological Medicine , Volume 47 , Issue 2 , January 2017 , pp. 199 - 208
Copyright
Copyright © Cambridge University Press 2016 

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